D-glucose as a regioselectively addressable scaffold for combinatorial chemistry on solid phase

被引：16
|
作者：
Peri, F
Nicotra, F
Leslie, CP
Micheli, F
Seneci, P
Marchioro, C
机构：
[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy
[2] GlaxoSmithKline SpA, Med Res Ctr, Verona, Italy
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 2003年 / 22卷 / 01期
关键词：
combinatorial chemistry; sugars; solid phase; scaffolds;
D O I：
10.1081/CAR-120019014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
D-Glucose derivatives bearing an anomeric thiophenyl group and orthogonally protections on secondary hydroxyl groups were linked to solid supports (PS/DV polymer, tentagel resin) through an ester bond on C-6. It was investigated the possibility to remove orthogonally protecting groups and functionalize selectively the free hydroxyls groups and the anomeric carbon of sugars in solid phase.
引用
收藏
页码：57 / 71
页数：15
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