D-glucose as a regioselectively addressable scaffold for combinatorial chemistry on solid phase

被引：16

作者：

Peri, F

Nicotra, F

Leslie, CP

Micheli, F

Seneci, P

Marchioro, C

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy

[2] GlaxoSmithKline SpA, Med Res Ctr, Verona, Italy

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2003年 / 22卷 / 01期

关键词：

combinatorial chemistry; sugars; solid phase; scaffolds;

D O I：

10.1081/CAR-120019014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-Glucose derivatives bearing an anomeric thiophenyl group and orthogonally protections on secondary hydroxyl groups were linked to solid supports (PS/DV polymer, tentagel resin) through an ester bond on C-6. It was investigated the possibility to remove orthogonally protecting groups and functionalize selectively the free hydroxyls groups and the anomeric carbon of sugars in solid phase.

引用

页码：57 / 71

页数：15

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