Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers

被引：13

作者：

Ramesh, Veera V. E. ^{[1
]}

Roy, Arup ^{[1
]}

Vijayadas, Kuruppanthara N. ^{[1
]}

Kendhale, Amol M. ^{[1
]}

Prabhakaran, Panchami ^{[1
]}

Gonnade, Rajesh ^{[2
]}

Puranik, Vedavati G. ^{[2
]}

Sanjayan, Gangadhar J. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

[2] Natl Chem Lab, Ctr Mat Characterizat, Pune 411008, Maharashtra, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 02期

关键词：

BETA-PEPTIDE; ENANTIOSELECTIVE SYNTHESIS; BINAPHTHOL DERIVATIVES; SECONDARY STRUCTURES; TURN MOTIFS; OLIGOMERS; CHIRALITY; HELICES; DESIGN; ACCESS;

D O I：

10.1039/c0ob00593b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This communication describes the development of conformationally constrained unnatural aromatic amino acids, constructed on rigid backbone wherein the carboxyl and amino groups project in two dimensions (planes) on the aromatic framework. Such a feature offers the possibility of design and development of conformationally ordered synthetic oligomers with intriguing structural architectures distinct from those classically observed. Furthermore, such amino acids will have the potential to extend the conformational space available for foldamer design with diverse backbone conformation and structural architectures.

引用

页码：367 / 369

页数：3

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