Triazinyl-amino acids, new building blocks for pseudopeptides

被引：0

作者：

Zerkowski, JA ^{[1
]}

Hensley, LM ^{[1
]}

Abramowitz, D ^{[1
]}

机构：

[1] Loyola Univ, Dept Chem, Chicago, IL 60626 USA

来源：

SYNLETT | 2002年 / 04期

关键词：

unnatural amino acids; peptides; macrocycles; peptidomimetics; triazines;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new heterocyclic building block for unnatural peptide analogues is described, and examples of its application are demonstrated. The 1,3,5-triazine nucleus is readily derivatized to possess an amino and a carboxy terminus, and the third site can be used to incorporate a wide variety of functional groups into an oligomer. This third site can also serve as the point of attachment to a solid-phase resin, allowing convenient construction of macrocyclic pseudopeptides that should be useful as clefts for molecular recognition studies or models of beta-strand conformation.

引用

页码：557 / 560

页数：4

共 50 条

[1] New Building Blocks or Dendritic Pseudopeptides for Metal Chelating
Ruan, M.
Abbour, S.
Mosbah, A.
Baudy-Floc'h, M.
[J]. JOURNAL OF PEPTIDE SCIENCE, 2012, 18 : S183 - S183
[2] New building blocks or dendritic pseudopeptides for metal chelating
Ruan, Min
Nicolas, Irene
Baudy-Floc'h, Michele
[J]. SPRINGERPLUS, 2016, 5
[3] New Preorganized γ-Amino Acids as Foldamer Building Blocks
Guo, Li
Zhang, Weicheng
Guzei, Ilia A.
Spencer, Lara C.
Gellman, Samuel H.
[J]. ORGANIC LETTERS, 2012, 14 (10) : 2582 - 2585
[4] New uses of amino acids as chiral building blocks in organic synthesis
Reetz, MT
Lee, WK
[J]. ORGANIC LETTERS, 2001, 3 (20) : 3119 - 3120
[5] Vinylogous γ-amino acids as building blocks for foldamers
Baldauf, C
Günther, R
Hofmann, HJ
[J]. BIOPOLYMERS, 2003, 71 (03) : 411 - 411
[6] Vinylogous γ-amino acids as building blocks for foldamers
Baldauf, Carsten
Guenther, Robert
Hofmann, Hans-Joerg
[J]. PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS, 2004, : 441 - 442
[7] CYCLITOL-ALPHA-AMINO ACIDS AS BUILDING BLOCKS IN NEW HYDROPHILIC FOLDAMERS
Van de Moortel, B.
Maes, T.
Caroen, J.
Goeman, J.
Van der Eycken, J.
[J]. JOURNAL OF PEPTIDE SCIENCE, 2014, 20 : S311 - S311
[8] Preparation of phosphinodipeptide analogs as building blocks for pseudopeptides synthesis
Cristau, HJ
Coulombeau, A
Genevois-Borella, A
Sanchez, F
Pirat, JL
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2002, 643 : 381 - 391
[9] Amino acids: Fuel, building blocks for proteins, and signals
Battezzati, A
Riso, P
[J]. NUTRITION, 2002, 18 (09) : 773 - 774
[10] Amino acids: Building blocks for the synthesis of greener amphiphiles
Joondan, Nausheen
Laulloo, Sabina Jhaumeer
Caumul, Prakashanand
[J]. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2018, 39 (11) : 1550 - 1564

← 1 2 3 4 5 →