Successful Treatment With ATRA and Arsenic Trioxide for a Child With Down Syndrome and Acute Promyelocytic Leukemia

被引：1

作者：

Tsumura, Yusuke ^{[1
]}

Yamada, Yuji ^{[1
]}

Osumi, Tomoo ^{[1
]}

Kato, Motohiro ^{[1
]}

Terashima, Keita ^{[1
]}

Shioda, Yoko ^{[1
]}

Kiyotani, Chikako ^{[1
]}

Matsumoto, Kimikazu ^{[1
]}

Tomizawa, Daisuke ^{[1
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 04期

关键词：

acute promyelocytic leukemia; Down syndrome; arsenic trioxide; all-trans retinoic acid; MYELOID-LEUKEMIA; CHEMOTHERAPY; CYTOGENETICS; REDUCTION; RELAPSE;

D O I：

10.1097/MPH.0000000000001438

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukemia (APL) is rare in patients with Down syndrome (DS). Cytotoxic chemotherapy combined with all-trans retinoic acid (ATRA) has been a standard treatment for APL, but is potentially intolerable for DS patients because of their vulnerability to cytotoxic agents. We report here a case of a 10-year-old girl with DS and APL successfully treated with a combination of ATRA and arsenic trioxide, a therapy emerging as a new standard for APL. She achieved molecular remission and completed the therapy without significant toxicities. ATRA/arsenic trioxide combination therapy would be a preferable option for DS patients with APL.

引用

页码：322 / 325

页数：4

共 50 条

[1] Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia
H. Agis
A. Weltermann
G. Mitterbauer
R. Thalhammer
M. Edelhäuser
H. L. Seewann
P. Valent
K. Lechner
C. Fonatsch
K. Geissler
[J]. Annals of Hematology, 1999, 78 : 329 - 332
[2] Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia
Agis, H
Weltermann, A
Mitterbauer, G
Thalhammer, R
Edelhäuser, M
Seewann, HL
Valent, P
Lechner, K
Fonatsch, C
Geissler, K
[J]. ANNALS OF HEMATOLOGY, 1999, 78 (07) : 329 - 332
[3] Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy
Ghavamzadeh, A
Alimoghaddam, K
Ghaffari, SH
Rostami, S
Jahani, M
Hosseini, R
Mossavi, A
Baybordi, E
Khodabadeh, A
Iravani, M
Bahar, B
Mortazavi, Y
Totonchi, M
Aghdami, N
[J]. ANNALS OF ONCOLOGY, 2006, 17 (01) : 131 - 134
[4] Molecular basis for the treatment of acute promyelocytic leukemia with ATRA and arsenic trioxide
Chen, Z
Chen, SJ
Wang, ZY
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1998, 102 (01) : 20 - 20
[5] ATRA/ARSENIC TRIOXIDE THERAPY FOR CHILDREN WITH ACUTE PROMYELOCYTIC LEUKEMIA
Minato, Sonoko
Gocho, Yoshihiro
Sakaguchi, Hirotoshi
Iguchi, Akihiro
Deguchi, Takao
Ohki, Kentarou
Kiyokawa, Takanobu
Matsumoto, Kimikazu
Tomizawa, Daisuke
[J]. PEDIATRIC BLOOD & CANCER, 2022, 69
[6] Successful treatment of a case of relapsed acute promyelocytic leukemia with arsenic trioxide
Hirayama, Y
Koyama, R
Nagai, T
Ohta, H
Kondo, A
Ishikawa, K
Ishitani, K
Matsunaga, T
Sakamaki, S
Niitsu, Y
[J]. INTERNAL MEDICINE, 2001, 40 (11) : 1136 - 1139
[7] First line treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and chemotherapy
Ghavamzadeh, A.
Alimoghaddam, K.
Ghaffari, S. A.
Rostami, S.
Jahani, M.
Iravani, M.
Hosseini, R.
Khodabandeh, A.
Mousavi, S. A.
Eini, E.
[J]. EJC SUPPLEMENTS, 2007, 5 (04): : 350 - 350
[8] Arsenic trioxide in treatment of acute promyelocytic leukemia
Ghavamzadeh, A
Alimoghddam, K
Aghdami, N
Rastegarpanah, M
Hosseini, R
Tavassoli, P
Jahani, M
Khodabandeh, A
Babordi, E
Irvani, M
Bahar, B
[J]. INTERNATIONAL JOURNAL OF CANCER, 2002, : 393 - 394
[9] Treatment of acute promyelocytic leukemia with arsenic trioxide
Tamm, I
Paternostro, G
Zapata, JM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (13): : 1043 - 1043
[10] Arsenic trioxide for the treatment of acute promyelocytic leukemia
Lam, MSH
Ignoffo, RJ
[J]. CANCER PRACTICE, 2001, 9 (03) : 155 - 157

← 1 2 3 4 5 →