Successful Treatment With ATRA and Arsenic Trioxide for a Child With Down Syndrome and Acute Promyelocytic Leukemia

被引：1

作者：

Tsumura, Yusuke ^{[1
]}

Yamada, Yuji ^{[1
]}

Osumi, Tomoo ^{[1
]}

Kato, Motohiro ^{[1
]}

Terashima, Keita ^{[1
]}

Shioda, Yoko ^{[1
]}

Kiyotani, Chikako ^{[1
]}

Matsumoto, Kimikazu ^{[1
]}

Tomizawa, Daisuke ^{[1
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 04期

关键词：

acute promyelocytic leukemia; Down syndrome; arsenic trioxide; all-trans retinoic acid; MYELOID-LEUKEMIA; CHEMOTHERAPY; CYTOGENETICS; REDUCTION; RELAPSE;

D O I：

10.1097/MPH.0000000000001438

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukemia (APL) is rare in patients with Down syndrome (DS). Cytotoxic chemotherapy combined with all-trans retinoic acid (ATRA) has been a standard treatment for APL, but is potentially intolerable for DS patients because of their vulnerability to cytotoxic agents. We report here a case of a 10-year-old girl with DS and APL successfully treated with a combination of ATRA and arsenic trioxide, a therapy emerging as a new standard for APL. She achieved molecular remission and completed the therapy without significant toxicities. ATRA/arsenic trioxide combination therapy would be a preferable option for DS patients with APL.

引用

页码：322 / 325

页数：4

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