alpha-Amino nitriles are synthesized by a one-pot three-component condensation reaction of amines, aldehydes and trimethylsilylcyanide in the presence of a catalytic amount of cellulose sulfuric acid as a bio-supported catalyst, in excellent yields with short reaction times at ambient temperature. The reaction work-up is simple and the catalyst can be easily separated from the product and reused in subsequent reactions. (C) 2007 Elsevier B.V. All rights reserved.
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Gansu Normal Univ Nationalities, Dept Chem, Hezuo 747000, Gansu, Peoples R ChinaGansu Normal Univ Nationalities, Dept Chem, Hezuo 747000, Gansu, Peoples R China
Yang, Jing-Jun
Dang, Ning
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Gansu Normal Univ Nationalities, Dept Chem, Hezuo 747000, Gansu, Peoples R ChinaGansu Normal Univ Nationalities, Dept Chem, Hezuo 747000, Gansu, Peoples R China
Dang, Ning
Chang, Yu-Wei
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Gansu Normal Univ Nationalities, Dept Chem, Hezuo 747000, Gansu, Peoples R ChinaGansu Normal Univ Nationalities, Dept Chem, Hezuo 747000, Gansu, Peoples R China