Potential anxiolytic- and antidepressant-like activity of Dipraglurant (ADX48621), the novel negative allosteric modulator (NAM) of the metabotropic glutamate 5 (mGlu5) receptor

被引：0
|
作者：
Podkowa, Karolina [1 ]
Palucha-Poniewiera, Agnieszka [1 ]
Poli, Sonia [2 ]
Pilc, Andrzej [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, Krakow, Poland
[2] Addex Pharmaceut SA, CH-1228 Geneva, Switzerland
来源：
PHARMACOLOGICAL REPORTS | 2015年 / 67卷
关键词：
D O I：
10.1016/j.pharep.2015.06.105
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：34 / 35
页数：2
相关论文
共 50 条
  • [41] 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP): A potent and highly selective metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
    Cosford, NDP
    Tehrani, L
    Arruda, J
    King, C
    McDonald, IA
    Munoz, B
    Roppe, J
    Schweiger, E
    Smith, N
    Wang, BW
    Zhang, KY
    Anderson, J
    Bristow, L
    Brodkin, J
    Rao, S
    Siegel, R
    Tattersall, D
    Washburn, M
    Prasit, P
    Varney, M
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U50 - U50
  • [42] Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity
    Rodriguez, Alice L.
    Grier, Mark D.
    Jones, Carrie K.
    Herman, Elizabeth J.
    Kane, Alexander S.
    Smith, Randy L.
    Williams, Richard
    Zhou, Ya
    Marlo, Joy E.
    Days, Emily L.
    Blatt, Tasha N.
    Jadhav, Satyawan
    Menon, Usha N.
    Vinson, Paige N.
    Rook, Jerri M.
    Stauffer, Shaun R.
    Niswender, Colleen M.
    Lindsley, Craig W.
    Weaver, C. David
    Conn, P. Jeffrey
    [J]. MOLECULAR PHARMACOLOGY, 2010, 78 (06) : 1105 - 1123
  • [43] Design, Synthesis, and Structure-Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5
    Burdi, Douglas F.
    Hunt, Rachel
    Fan, Lei
    Hu, Tao
    Wang, Jun
    Guo, Zihong
    Huang, Zhiqiang
    Wu, Chengde
    Hardy, Larry
    Detheux, Michel
    Orsini, Michael A.
    Quinton, Maria S.
    Lew, Robert
    Spear, Kerry
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (19) : 7107 - 7118
  • [44] 3-[(2-methyl-1,3-thiazol4-yl)etrynyl]pyredine (MTEP): Design and synthesis of a potent and highly selective metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
    Cosford, NDP
    Tehrani, L
    Arruda, J
    King, C
    McDonald, IA
    Munoz, B
    Roppe, J
    Anderson, E
    Bristow, L
    Brodkin, J
    Rao, S
    Siegel, R
    Tattersall, D
    Washburn, M
    Prasit, P
    Varney, M
    [J]. NEUROPHARMACOLOGY, 2002, 43 (02) : 282 - 283
  • [45] A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease
    Keywood, C.
    Wakefield, M.
    Tack, J.
    [J]. GUT, 2009, 58 (09) : 1192 - 1199
  • [46] Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound
    Mueller, Ralf
    Dawson, Eric S.
    Meiler, Jens
    Rodriguez, Alice L.
    Chauder, Brian A.
    Bates, Brittney S.
    Felts, Andrew S.
    Lamb, Jeffrey P.
    Menon, Usha N.
    Jadhav, Sataywan B.
    Kane, Alexander S.
    Jones, Carrie K.
    Gregory, Karen J.
    Niswender, Colleen M.
    Conn, P. Jeffrey
    Olsen, Christopher M.
    Winder, Danny G.
    Emmitte, Kyle A.
    Lindsley, Craig W.
    [J]. CHEMMEDCHEM, 2012, 7 (03) : 406 - 414
  • [47] Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators
    Kubas, Holger
    Meyer, Udo
    Krueger, Bjoern
    Hechenberger, Mirko
    Vanejevs, Maksims
    Zemribo, Ronalds
    Kauss, Valerjans
    Ambartsumova, Raisa
    Pyatkin, Ilya
    Polosukhin, Alexey I.
    Abel, Ulrich
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (16) : 4493 - 4500
  • [48] Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
    Bridges, Thomas M.
    Rook, Jerri M.
    Noetzel, Meredith J.
    Morrison, Ryan D.
    Zhou, Ya
    Gogliotti, Rocco D.
    Vinson, Paige N.
    Xiang, Zixiu
    Jones, Carrie K.
    Niswender, Colleen M.
    Lindsley, Craig W.
    Stauffer, Shaun R.
    Conn, P. Jeffrey
    Daniels, J. Scott
    [J]. DRUG METABOLISM AND DISPOSITION, 2013, 41 (09) : 1703 - 1714
  • [49] A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice
    Zanos, Panos
    Nelson, Mackenzie E.
    Highland, Jaclyn N.
    Krimmel, Samuel R.
    Georgiou, Polymnia
    Gould, Todd D.
    Thompson, Scott M.
    [J]. ENEURO, 2017, 4 (01)
  • [50] Broad Spectrum Activity of the mGluR5 Negative Allosteric Modulator, GRN-529, in Preclinical Anxiolytic, Antidepressant and Analgesic Models Suggests the Potential for Efficacy in Treatment Resistant Depression
    Hughes, Z. A.
    Neal, S. J.
    Smith, D. L.
    Rizzo, S. J. Sukoff
    Pulicicchio, C. M.
    Lotarski, S.
    Bryce, D.
    Lu, S.
    Dwyer, J. M.
    Olsen, M.
    Bender, C. N.
    Kouranova, E.
    Springer, D.
    Li, D.
    O'Neil, S. V.
    Andree, T. H.
    Whiteside, G. T.
    Dunlop, J.
    Brandon, N. J.
    Schechter, L. E.
    Leonard, S. K.
    Rosenzweig-Lipson, S.
    Ring, R. H.
    [J]. CURRENT NEUROPHARMACOLOGY, 2011, 9 : 29 - 29
12345