Potential anxiolytic- and antidepressant-like activity of Dipraglurant (ADX48621), the novel negative allosteric modulator (NAM) of the metabotropic glutamate 5 (mGlu5) receptor

被引：0
|
作者：
Podkowa, Karolina [1 ]
Palucha-Poniewiera, Agnieszka [1 ]
Poli, Sonia [2 ]
Pilc, Andrzej [1 ]
机构：
[1] Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, Krakow, Poland
[2] Addex Pharmaceut SA, CH-1228 Geneva, Switzerland
来源：
PHARMACOLOGICAL REPORTS | 2015年 / 67卷
关键词：
D O I：
10.1016/j.pharep.2015.06.105
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：34 / 35
页数：2
相关论文
共 50 条
  • [31] ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats
    Marszalek-Grabska, Marta
    Gibula-Bruzda, Ewa
    Bodzon-Kulakowska, Anna
    Suder, Piotr
    Gawel, Kinga
    Talarek, Sylwia
    Listos, Joanna
    Kedzierska, Ewa
    Danysz, Wojciech
    Kotlinska, Jolanta H.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2018, 338 : 9 - 16
  • [32] Fragment-based GPCR drug discovery using a stabilised receptor (StaR): Identification of an mGlu5 negative allosteric modulator (NAM) pre-clinical candidate
    Christopher, John A.
    Aves, Sarah J.
    Bennett, Kirstie A.
    Congreve, Miles
    Jazayeri, Ali
    Khan, Samir Ali
    Patel, Jayesh C.
    Tehan, Benjamin
    Wiggin, Gisselle
    Marshall, Fiona H.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [33] Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice
    Du, Yonglei
    Gao, Feng
    Sun, Hongwei
    Wu, Chenglin
    Zhu, Guoqi
    Zhu, Manzhou
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 261
  • [34] Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM
    Sheffler, Douglas J.
    Wenthur, Cody J.
    Bruner, Joshua A.
    Carrington, Sheridan J. S.
    Vinson, Paige N.
    Gogi, Kiran K.
    Blobaum, Anna L.
    Morrison, Ryan D.
    Vamos, Mitchell
    Cosford, Nicholas D. P.
    Stauffer, Shaun R.
    Daniels, J. Scott
    Niswender, Colleen M.
    Conn, P. Jeffrey
    Lindsley, Craig W.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (12) : 3921 - 3925
  • [35] Partial mGlu5 receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice
    Palucha-Poniewiera, Agnieszka
    Rafalo-Ulinska, Anna
    Santocki, Michal
    Babii, Yana
    Kaczorowska, Katarzyna
    [J]. PHARMACOLOGICAL REPORTS, 2024, 76 (03) : 504 - 518
  • [36] A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models
    Kinney, GG
    O'Brien, JA
    Lemaire, W
    Burno, M
    Bickel, DJ
    Clements, MK
    Chen, TB
    Wisnoski, DD
    Lindsley, CW
    Tiller, PR
    Smith, S
    Jacobson, MA
    Sur, C
    Duggan, ME
    Pettibone, DJ
    Conn, PJ
    Williams, DL
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01): : 199 - 206
  • [37] Discovery and structure-activity relationship studies of 1,3-cyclohexyl-diamides as novel mGlu5 receptor negative allosteric modulators
    Zhou, Hao
    Grenon, Michel
    Li, Guiying
    Jimenez, Hermogenes N.
    Bonvicino, Christina L.
    Pu, Xiaosui
    Topiol, Sidney W.
    Brodbeck, Robbin M.
    Chandrasena, Gamini
    Doller, Dario
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [38] Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pH-impedance study in healthy subjects
    Zerbib, F.
    Keywood, C.
    Strabach, G.
    [J]. NEUROGASTROENTEROLOGY AND MOTILITY, 2010, 22 (08): : 859 - E231
  • [39] 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP): A potent and highly selective metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
    Varney, M
    Anderson, J
    Bradbury, M
    Bristow, L
    Brodkin, J
    Giracello, D
    Jachec, C
    Holtz, G
    Prasit, P
    Rao, S
    Chapman, D
    Cosford, NDP
    [J]. NEUROPHARMACOLOGY, 2002, 43 (02) : 311 - 311
  • [40] 5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-2,3′-bipyridine:: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity
    Roppe, JR
    Wang, BW
    Huang, DH
    Tehrani, L
    Kamenecka, T
    Schweiger, EJ
    Anderson, JJ
    Brodkin, J
    Jiang, XH
    Cramer, M
    Chung, J
    Reyes-Manalo, G
    Munoz, B
    Cosford, NDP
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) : 3993 - 3996
12345