EGF receptor as a therapeutic target

被引：46
|
作者：
Levitzki, A [1 ]
机构：
[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, Unit Cell Signaling, IL-91904 Jerusalem, Israel
来源：
LUNG CANCER | 2003年 / 41卷
关键词：
EGFR; Her-2; tyrphostins; lung cancer;
D O I：
10.1016/S0169-5002(03)00134-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
EGFR and Her-2 are overexpressed in lung cancers and have, therefore, been chosen as preferred targets for novel therapies. Recent results on Iressa trials show only a moderate response to the agent, even in cases where it is documented that EGFR is over-expressed. These findings prompted us to re-visit the oncogenic pathways, which play a rote in lung cancers, with special emphasis on the way EGFR/ Her-2 signaling cooperates with other signaling pathways. (C) 2003 Elsevier Science Ireland Ltd and Ainerican Society of Clinical Oncology. Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：S9 / S14
页数：6
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