EGF receptor as a therapeutic target

被引：46
|
作者：
Levitzki, A [1 ]
机构：
[1] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Biol Chem, Unit Cell Signaling, IL-91904 Jerusalem, Israel
来源：
LUNG CANCER | 2003年 / 41卷
关键词：
EGFR; Her-2; tyrphostins; lung cancer;
D O I：
10.1016/S0169-5002(03)00134-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
EGFR and Her-2 are overexpressed in lung cancers and have, therefore, been chosen as preferred targets for novel therapies. Recent results on Iressa trials show only a moderate response to the agent, even in cases where it is documented that EGFR is over-expressed. These findings prompted us to re-visit the oncogenic pathways, which play a rote in lung cancers, with special emphasis on the way EGFR/ Her-2 signaling cooperates with other signaling pathways. (C) 2003 Elsevier Science Ireland Ltd and Ainerican Society of Clinical Oncology. Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：S9 / S14
页数：6
相关论文
共 50 条
  • [21] The folate receptor as a potential therapeutic anticancer target
    Gruner, BA
    Weitman, SD
    INVESTIGATIONAL NEW DRUGS, 1998, 16 (03) : 205 - 219
  • [22] Estrogen Receptor β Is a Novel Therapeutic Target for Photoaging
    Chang, Ken C. N.
    Wang, Yihe
    Oh, Inn Gyung
    Jenkins, Susan
    Freedman, Leonard P.
    Thompson, Catherine C.
    Chung, Jin Ho
    Nagpal, Sunil
    MOLECULAR PHARMACOLOGY, 2010, 77 (05) : 744 - 750
  • [23] The folate receptor as a potential therapeutic anticancer target
    Barbara A. Gruner
    Steven D. Weitman
    Investigational New Drugs, 1998, 16 : 205 - 219
  • [24] ANDROGEN RECEPTOR IS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA
    Zalsman, Nomi
    Canello, Tamar
    Ovadia, Haim
    Charbit, Hanna
    Zelikovitch, Bracha
    Mordechai, Anat
    Fellig, Yakov
    Rabani, Stav
    Shahar, Tal
    Lossos, Alexander
    Lavon, Iris
    NEURO-ONCOLOGY, 2017, 19 : 54 - 55
  • [25] The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders
    Braat, Sien
    Kooy, R. Frank
    NEURON, 2015, 86 (05) : 1119 - 1130
  • [26] Estrogen receptor beta as a tractable therapeutic target
    Filgueira, Carly S.
    Benod, Cindy
    Lou, Xiaohua
    Strom, Anders
    Gustafsson, Jan-Ake
    Berkenstam, Anders
    Webb, Paul
    CANCER RESEARCH, 2015, 75
  • [27] Glutamatergic NMDA Receptor as Therapeutic Target for Depression
    Reus, Gislaine Z.
    Abelaira, Helena M.
    Tuon, Talita
    Titus, Stephanie E.
    Ignacio, Zuleide M.
    Rodrigues, Ana Lucia S.
    Quevedo, Joao
    ION CHANNELS AS THERAPEUTIC TARGETS, PT A, 2016, 103 : 169 - 202
  • [28] Farnesoid X receptor as a therapeutic target for dyslipidemia
    Evans, Mark J.
    Gardell, Stephen J.
    CLINICAL LIPIDOLOGY, 2009, 4 (05) : 587 - 594
  • [29] Modulation of receptor sensitivity: possible therapeutic target?
    Cohen, Michel V.
    Downey, James M.
    BRITISH JOURNAL OF PHARMACOLOGY, 2009, 156 (06) : 899 - 900
  • [30] The CCR2 receptor as a therapeutic target
    Feria, M
    Díaz-González, F
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (01) : 49 - 57
12345