Synthesis, structure and anticancer studies of Cu( II ) and Ni( II ) complexes based on 2-hydroxy-1-naphthaldehyde-4-aminoantipyrine Schiff-base

被引：6

作者：

Qi, Jiajia ^{[1
]}

Luo, Yun ^{[1
]}

Zhou, Qianxi ^{[1
]}

Su, Guozhen ^{[1
]}

Zhang, Xuan ^{[1
]}

Nie, Xuegang ^{[1
]}

Lv, Mingyue ^{[1
]}

Li, Wenge ^{[1
]}

机构：

[1] Bengbu Med Coll, Dept Chem, Bengbu 233030, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1255卷

关键词：

Schiff-base; Nickel complex; Copper complex; Crystal structure; Cytoxicity studies; METAL-COMPLEXES; HETEROCYCLIC-COMPOUNDS; CHEMISTRY; DNA;

D O I：

10.1016/j.molstruc.2022.132458

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Two metal-organic complexes of [CuLCl] (1), and [Ni2L2(C2H5OH)(2)Cl-2]center dot 2(C2H5OH)(2)(2) (HL= 2-hydroxy-1-naphthaldehyde-4-aminoantipyrine) were solvothermally synthesized from Schiff-base ligands. Single-crystal X-ray diffraction analysis shows that the mononuclear complex 1 is monoclinic while the dinuclear complex 2 belongs to triclinic crystal structure and the two complexes are both monomer molecules. Additionally, the cancer cytotoxicity, cell migration, and apoptosis properties of both complexes have been investigated. Owing to different coordination behavior between Ni(II) and Cu(II), it was found that com-plex 1 obviously displayed cytotoxicity and decreased cell migration rate by inducing apoptosis of SMMC-7721 cells (hepatoma carcinoma cells). (c) 2022 Published by Elsevier B.V.

引用

页数：12

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