Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia

被引：46
|
作者：
Chu, TW
Hu, SW
Wei, B
Wang, Y
Liu, XQ
Wang, XY [1 ]
机构：
[1] Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期
基金：
中国国家自然科学基金;
关键词：
4-nitroimidazole; hypoxia imaging agent; biodistribution; tumor;
D O I：
10.1016/j.bmcl.2003.11.017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N41PA) was synthesized. The biodistribution of Tc-99m-N41PA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that Tc-99m-N41PA would be a marker for imaging tumor hypoxia. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：747 / 749
页数：3
相关论文
共 50 条
  • [41] Flux through multicellular layers of a technetium-99m-nitroimidazole for imaging hypoxia
    Melo, T
    Tunggal, JK
    Ballinger, JR
    Rauth, AM
    CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2002, 17 (05) : 515 - 526
  • [42] Preparation and biodistribution of technetium-99m-labeled 1-(2-nitroimidazole-1-yl)-propanhydroxyimino amide (N21PA) as a tumor hypoxia marker
    Chu, TW
    Li, RJ
    Hu, SW
    Liu, XQ
    Wang, XY
    NUCLEAR MEDICINE AND BIOLOGY, 2004, 31 (02) : 199 - 203
  • [43] RADIATION ABSORBED DOSE FROM TECHNETIUM-99M-LABELED BONE IMAGING AGENTS
    WEBER, DA
    MAKLER, PT
    WATSON, EE
    COFFEY, JL
    THOMAS, SR
    LONDON, J
    JOURNAL OF NUCLEAR MEDICINE, 1989, 30 (06) : 1117 - 1122
  • [44] Radiodiagnosis of peptic ulcer with technetium-99m-labeled esomeprazole
    Sanad M.H.
    Talaat H.M.
    Radiochemistry, 2017, 59 (4) : 396 - 401
  • [45] PLACENTAL LOCALIZATION USING TECHNETIUM-99M-LABELED ALBUMIN
    JACOBY, H
    ARNOT, RN
    JEYASINGH, K
    GLASS, HI
    BROWNE, JCM
    OBSTETRICS AND GYNECOLOGY, 1969, 33 (03): : 358 - +
  • [46] Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates
    Pathuri, Gopal
    Hedrick, Andria F.
    Disch, Bryan C.
    Ihnat, Michael A.
    Awasthi, Vibhudutta
    Gali, Hariprasad
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (14) : 4567 - 4570
  • [47] Technetium-99m-labeled doxorubicin as an imaging probe for murine breast tumor (4T1 cell line) identification
    Fernandes, Renata S.
    Silva, Juliana de Oliveira
    Lopes, Savia C. A.
    Chondrogiannis, Sotirios
    Rubello, Domenico
    Cardoso, Valbert N.
    Oliveira, Monica C.
    Ferreira, Lucas A. M.
    de Barros, Andre L. B.
    NUCLEAR MEDICINE COMMUNICATIONS, 2016, 37 (03) : 307 - 312
  • [48] Synthesis and Bioevaluation of Novel Technetium-99m-Labeled Complexes with Norfloxacin HYNIC Derivatives for Bacterial Infection Imaging
    Jiang, Yuhao
    Fang, Si'an
    Feng, Junhong
    Ruan, Qing
    Zhang, Junbo
    MOLECULAR PHARMACEUTICS, 2023, 20 (01) : 630 - 640
  • [49] Synthesis and biological evaluation of a novel 99mTc labeled 2-nitroimidazole derivative as a potential agent for imaging tumor hypoxia
    Joyard, Yoann
    Le Joncour, Vadim
    Castel, Helene
    Diouf, Cherif Bounana
    Bischoff, Laurent
    Papamicael, Cyril
    Levacher, Vincent
    Vera, Pierre
    Bohn, Pierre
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (13) : 3704 - 3708
  • [50] Serial evaluation of myocardial hypoxia post myocardial infarction with technetium-99m labeled nitroimidazole
    Sinusas, AJ
    Meoli, DF
    Sadeghi, MM
    Bourke, BN
    Hu, J
    Brown, LM
    Krassilnikova, S
    Zaret, BL
    CIRCULATION, 2002, 106 (19) : 581 - 581
12345