Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia

被引：46
|
作者：
Chu, TW
Hu, SW
Wei, B
Wang, Y
Liu, XQ
Wang, XY [1 ]
机构：
[1] Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期
基金：
中国国家自然科学基金;
关键词：
4-nitroimidazole; hypoxia imaging agent; biodistribution; tumor;
D O I：
10.1016/j.bmcl.2003.11.017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N41PA) was synthesized. The biodistribution of Tc-99m-N41PA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that Tc-99m-N41PA would be a marker for imaging tumor hypoxia. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：747 / 749
页数：3
相关论文
共 50 条
  • [11] [99mTc(CO)3]+ labeled histidine derivative containing 4-nitroimidazole: Synthesis, biodistribution as a tumor hypoxia imaging agent
    Me Lei
    Chu Taiwei
    NUCLEAR SCIENCE AND TECHNIQUES, 2011, 22 (02) : 105 - 110
  • [12] Synthesis and biological evaluation of novel technetium-99m-labeled HYNIC-D-glucose as a potential tumor imaging agent
    Liu, Liqin
    Zhao, Manchen
    Wang, Zhuo
    Qin, Yuanyan
    Wang, Xuebin
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2014, 301 (03) : 731 - 737
  • [13] Synthesis and biological evaluation of novel technetium-99m-labeled HYNIC-d-glucose as a potential tumor imaging agent
    Liqin Liu
    Manchen Zhao
    Zhuo Wang
    Yuanyan Qin
    Xuebin Wang
    Journal of Radioanalytical and Nuclear Chemistry, 2014, 301 : 731 - 737
  • [14] IMAGING OF INFLAMMATORY ARTHRITIS WITH TECHNETIUM-99M-LABELED IGG
    BREEDVELD, FC
    VANKROONENBURGH, MJPG
    CAMPS, JAJ
    FEITSMA, HIJ
    MARKUSSE, HM
    PAUWELS, EKJ
    JOURNAL OF NUCLEAR MEDICINE, 1989, 30 (12) : 2017 - 2021
  • [15] IMAGING OF ATHEROSCLEROSIS WITH TECHNETIUM-99M-LABELED LDL IN HUMANS
    LEES, RS
    ISAACSOHN, J
    LEES, AM
    FISCHMAN, AJ
    STRAUSS, HW
    BARLAIKOVACH, M
    ARTERIOSCLEROSIS, 1985, 5 (05): : A511 - A512
  • [16] Biological evaluation and SPECT imaging of tumor hypoxia using a novel technetium-99m labeled tracer with 2-nitroimidazole moiety
    Xiao Lin
    Qing Ruan
    Ling Lin
    Xuran Zhang
    Xiaojiang Duan
    Yanguo Teng
    Junbo Zhang
    Journal of Radioanalytical and Nuclear Chemistry, 2018, 317 : 1463 - 1468
  • [17] Biological evaluation and SPECT imaging of tumor hypoxia using a novel technetium-99m labeled tracer with 2-nitroimidazole moiety
    Lin, Xiao
    Ruan, Qing
    Lin, Ling
    Zhang, Xuran
    Duan, Xiaojiang
    Teng, Yanguo
    Zhang, Junbo
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2018, 317 (03) : 1463 - 1468
  • [18] SCINTIGRAPHIC IMAGING OF TECHNETIUM-99M-LABELED NEUTROPHILS IN THE DOG
    MOON, ML
    HINKLE, GN
    KRAKOWKA, GS
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 1988, 49 (06) : 950 - 955
  • [19] Synthesis and Evaluation of Technetium-99m-Labeled Bioreductive Pharmacophores Conjugated with Amino Acids and Peptides for Tumor Imaging
    Baishya, Rinku
    Nayak, Dipak K.
    Karmakar, Sanmoy
    Chattopadhyay, Sankha
    Sachdeva, Satbir S.
    Sarkar, Bharat R.
    Ganguly, Shantanu
    Debnath, Mita C.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 85 (04) : 504 - 517
  • [20] Synthesis and biodistribution of novel 99mTc labeled 4-nitroimidazole dithiocarbamate complexes as potential agents to target tumor hypoxia
    Li, Zhenxiang
    Zhang, Junbo
    Jin, Zhonghui
    Zhang, Weifang
    Zhang, Yanyan
    MEDCHEMCOMM, 2015, 6 (06) : 1143 - 1148
12345