Tolerogenic dendritic cells in health and disease:: friend and foe!

被引：0
|
作者：
Adler, Henric S. [1 ]
Steinbrink, Kerstin [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Dept Dermatol, D-6500 Mainz, Germany
来源：
EUROPEAN JOURNAL OF DERMATOLOGY | 2007年 / 17卷 / 06期
关键词：
dendritic cells; peripheral tolerance; regulatory T cells; IL-10;
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dendritic cells (DC) are professional antigen presenting cells and crucial mediators of immune defence and tolerance. Experimental evidence in vitro and in vivo has shown that tolerogenic DCs (tDCs) contribute to prevention of autoimmunity and allergic reactions but might also worsen the course of cancer and certain infectious diseases. The development of in vitro protocols for the generation of human tDCs has greatly improved the knowledge of basic principles for tolerance induction by tDCs and fosters approaches for the therapeutic manipulation of tDCs in conditions such as severe autoimmunity, allergy or transplantation.
引用
收藏
页码：476 / 491
页数：16
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