CpG motif-based adjuvant as a replacement for Freund's complete adjuvant in a recombinant LHRH vaccine

被引：19
|
作者：
Conforti, Valeria A. [1 ]
De Avila, David M. [1 ]
Curnmings, Nada S. [1 ]
Zanella, Ricardo [1 ]
Wells, Kenny J. [1 ]
Uelker, Hasan [2 ]
Reeves, Jerry J. [1 ]
机构：
[1] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA
[2] Yuzuncu Yil Univ, Ziraat Fac, Dept Anim Sci, TR-65080 Van, Turkey
来源：
VACCINE | 2008年 / 26卷 / 07期
关键词：
LHRH immunization; CpG ODN; Freund's adjuvant;
D O I：
10.1016/j.vaccine.2007.12.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study compared: (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n = 8 heifers/group) were: one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. Ail vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：907 / 913
页数：7
相关论文
共 50 条
  • [31] Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently
    Joanna E. Fishback
    Sabrina M. Stronsky
    Catherine A. Green
    Krystal D. Bean
    Jeffrey W. Froude
    Lab Animal, 2016, 45 : 63 - 66
  • [32] Effect of Losartan in Complete Freund's Adjuvant-Induced Arthritis in Rats
    El-Gaphar, Omnia Ahmed Mohamed Abdel
    Abo-Youssef, Amira Mourad
    Abo-Saif, Ali Ahmed
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (04): : 1420 - 1430
  • [33] Regulation of autoimmune diabetes by complete Freund's adjuvant is mediated by NK cells
    Lee, IF
    Qin, HL
    Trudeau, J
    Dutz, J
    Tan, RS
    JOURNAL OF IMMUNOLOGY, 2004, 172 (02): : 937 - 942
  • [34] Combined atorvastatin and pentoxifylline in ameliorating inflammation induced by complete Freund’s adjuvant
    Sahar Etemadi
    Seyyed Meysam Abtahi Froushani
    Seyyed Mohammad Hashemi Asl
    Alireza Mahmoudian
    Inflammopharmacology, 2022, 30 : 935 - 944
  • [35] Insulin Is Essential for the Recovery from Allodynia Induced by Complete Freund's Adjuvant
    Casey, Gregory P.
    Paul, Dennis
    Gould, Harry J., III
    PAIN MEDICINE, 2010, 11 (09) : 1401 - 1410
  • [36] Anti-inflammatory effect of stevioside abates Freund's complete adjuvant (FCA)-induced adjuvant arthritis in rats
    Alavala, Sateesh
    Nalban, Nasiruddin
    Sangaraju, Rajendra
    Kuncha, Madhusudana
    Jerald, Mahesh Kumar
    Kilari, Eswar Kumar
    Sistla, Ramakrishna
    INFLAMMOPHARMACOLOGY, 2020, 28 (06) : 1579 - 1597
  • [37] Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats
    Sateesh Alavala
    Nasiruddin Nalban
    Rajendra Sangaraju
    Madhusudana Kuncha
    Mahesh Kumar Jerald
    Eswar Kumar Kilari
    Ramakrishna Sistla
    Inflammopharmacology, 2020, 28 : 1579 - 1597
  • [38] Metabolic changes induced by complete Freund's adjuvant resemble the features of trained immunity
    Mone, Kiruthiga
    Seravalli, Javier
    Reddy, Jay
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [39] Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently
    Joanna E. Fishback
    Sabrina M. Stronsky
    Catherine A. Green
    Krystal D. Bean
    Jeffrey W. Froude
    Lab Animal, 2016, 45 : 121 - 121
  • [40] Freund's vaccine adjuvant promotes Her2/Neu breast cancer
    Cotroneo, Michelle S.
    Haag, Jill D.
    Stapel, Nicholas R.
    Waller, Jordy L.
    Woditschka, Stephan
    Gould, Michael N.
    BMC CANCER, 2009, 9
12345