Lewis acid-catalyzed [3+2] annulations of oxindole based spirocyclic donor-acceptor cyclopropanes with ynamides

被引：8

作者：

Zhang, Dongxin ^{[1
]}

Cheng, Qihang ^{[1
]}

Chen, Lvjia ^{[1
]}

Deng, Huiqing ^{[1
]}

Cai, Hu ^{[1
]}

Zhang, Qian-Feng ^{[1
]}

机构：

[1] Anhui Univ Technol, Inst Mol Engn & Appl Chem, 59 Hudong Rd, Maanshan 243002, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 44期

关键词：

BAYLIS-HILLMAN CARBONATES; DIASTEREOSELECTIVE CONSTRUCTION; ENANTIOSELECTIVE CONSTRUCTION; SPIROOXINDOLES; STRATEGY; ISATINS; DESIGN;

D O I：

10.1039/d1ob01922h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[3 + 2] annulations of oxindole based spirocyclic donor-acceptor cyclopropanes and ynamides catalyzed by copper triflate have been developed for the synthesis of biologically important spirocyclopenteneoxindoles. These reactions tolerated a wide scope of substrates and provided the desired products in good to high yields (up to 90%) with up to >40 : 1 diastereoselectivities under mild conditions.

引用

页码：9645 / 9648

页数：4

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