Lewis acid-catalyzed [3+2] annulations of oxindole based spirocyclic donor-acceptor cyclopropanes with ynamides

被引：8
|
作者：
Zhang, Dongxin [1 ]
Cheng, Qihang [1 ]
Chen, Lvjia [1 ]
Deng, Huiqing [1 ]
Cai, Hu [1 ]
Zhang, Qian-Feng [1 ]
机构：
[1] Anhui Univ Technol, Inst Mol Engn & Appl Chem, 59 Hudong Rd, Maanshan 243002, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 44期
关键词：
BAYLIS-HILLMAN CARBONATES; DIASTEREOSELECTIVE CONSTRUCTION; ENANTIOSELECTIVE CONSTRUCTION; SPIROOXINDOLES; STRATEGY; ISATINS; DESIGN;
D O I：
10.1039/d1ob01922h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[3 + 2] annulations of oxindole based spirocyclic donor-acceptor cyclopropanes and ynamides catalyzed by copper triflate have been developed for the synthesis of biologically important spirocyclopenteneoxindoles. These reactions tolerated a wide scope of substrates and provided the desired products in good to high yields (up to 90%) with up to >40 : 1 diastereoselectivities under mild conditions.
引用
收藏
页码：9645 / 9648
页数：4
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