Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape

被引：40
|
作者：
Lou, Fuxing [1 ]
Li, Maochen [1 ]
Pang, Zehan [1 ]
Jiang, Lin [1 ]
Guan, Lin [1 ]
Tian, Lili [1 ]
Hu, Jiaming [2 ]
Fan, Junfen [3 ,4 ]
Fan, Huahao [1 ]
机构：
[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China
[2] NYU, Tendon Sch Engn, New York, NY USA
[3] Capital Med Univ, Xuanwu Hosp, Inst Cerebrovasc Dis Res, Beijing, Peoples R China
[4] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
SARS-CoV-2; variants; immune escape; vaccine; neutralizing antibody; variants of interest; variants of concern; RECEPTOR-BINDING DOMAIN; SPIKE; ANTIBODY; VACCINE; MUTATIONS; B.1.1.7; NEUTRALIZATION; TRANSMISSION; EMERGENCE; COVID-19;
D O I：
10.3389/fimmu.2021.744242
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The global pandemic of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), places a heavy burden on global public health. Four SARS-CoV-2 variants of concern including B.1.1.7, B.1.351, B.1.617.2, and P.1, and two variants of interest including C.37 and B.1.621 have been reported to have potential immune escape, and one or more mutations endow them with worrisome epidemiologic, immunologic, or pathogenic characteristics. This review introduces the latest research progress on SARS-CoV-2 variants of interest and concern, key mutation sites, and their effects on virus infectivity, mortality, and immune escape. Moreover, we compared the effects of various clinical SARS-CoV-2 vaccines and convalescent sera on epidemic variants, and evaluated the neutralizing capability of several antibodies on epidemic variants. In the end, SARS-CoV-2 evolution strategies in different transmission stages, the impact of different vaccination strategies on SARS-CoV-2 immune escape, antibody therapy strategies and COVID-19 epidemic control prospects are discussed. This review will provide a systematic and comprehensive understanding of the secret of SARS-CoV-2 variants of interest/concern and immune escape.
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收藏
页数：19
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