mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

被引：544

作者：

Goel, Rishi R. ^{[1
,2
]}

Painter, Mark M. ^{[1
,2
]}

Apostolidis, Sokratis A. ^{[1
,2
,3
]}

Mathew, Divij ^{[1
,2
]}

Meng, Wenzhao ^{[1
,4
]}

Rosenfeld, Aaron M. ^{[1
,4
]}

Lundgreen, Kendall A. ^{[5
]}

Reynaldi, Arnold ^{[6
]}

Khoury, David S. ^{[6
]}

Pattekar, Ajinkya ^{[2
]}

Gouma, Sigrid ^{[5
]}

Kuri-Cervantes, Leticia ^{[1
,5
]}

Hicks, Philip ^{[5
]}

Dysinger, Sarah ^{[5
]}

Hicks, Amanda ^{[2
]}

Sharma, Harsh ^{[2
]}

Herring, Sarah ^{[2
]}

Korte, Scott ^{[2
]}

Baxter, Amy E. ^{[1
]}

Oldridge, Derek A. ^{[1
,4
]}

Giles, Josephine R. ^{[1
,7
,8
]}

Weirick, Madison E. ^{[5
]}

McAllister, Christopher M. ^{[5
]}

Awofolaju, Moses ^{[5
]}

Tanenbaum, Nicole ^{[5
]}

Drapeau, Elizabeth M. ^{[5
]}

Dougherty, Jeanette ^{[1
]}

Long, Sherea ^{[1
]}

D'Andrea, Kurt ^{[1
]}

Hamilton, Jacob T. ^{[2
,5
]}

McLaughlin, Maura ^{[1
]}

Williams, Justine C. ^{[2
]}

Adamski, Sharon ^{[2
]}

Kuthuru, Oliva ^{[1
]}

Frank, Ian ^{[9
]}

Betts, Michael R. ^{[1
,5
]}

Vella, Laura A. ^{[10
]}

Grifoni, Alba ^{[11
]}

Weiskopf, Daniela ^{[11
]}

Sette, Alessandro ^{[11
,12
]}

Hensley, Scott E. ^{[5
]}

Davenport, Miles P. ^{[6
]}

Bates, Paul ^{[5
]}

Prak, Eline T. Luning ^{[1
,4
]}

Greenplate, Allison R. ^{[1
,2
]}

Wherry, E. John ^{[1
,2
,7
,8
]}

机构：

[1] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Immune Hlth, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Div Rheumatol, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Univ New South Wales, Kirby Inst, Sydney, NSW, Australia

[7] Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA

[8] Univ Penn, Parker Inst Canc Immunotherapy, Perelman Sch Med, Philadelphia, PA 19104 USA

[9] Univ Penn, Div Infect Dis, Perelman Sch Med, Philadelphia, PA 19104 USA

[10] Childrens Hosp Philadelphia, Dept Pediat, Div Infect Dis, Philadelphia, PA 19104 USA

[11] La Jolla Inst Immunol LJI, Ctr Infect Dis & Vaccine Res, La Jolla, CA USA

[12] Univ Calif San Diego UCSD, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA USA

来源：

SCIENCE | 2021年 / 374卷 / 6572期

基金：

英国医学研究理事会; 澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

CELL; EXPLORATION; INFECTION; SYSTEM;

D O I：

10.1126/science.abm0829

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this study, we longitudinally profiled vaccine responses in SARS-CoV-2-naive and -recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months. By contrast, mRNA vaccines generated functional memory B cells that increased from 3 to 6 months postvaccination, with the majority of these cells cross-binding the Alpha, Beta, and Delta variants. mRNA vaccination further induced antigen-specific CD4(+) and CD8(+) T cells, and early CD4(+) T cell responses correlated with long-term humoral immunity. Recall responses to vaccination in individuals with preexisting immunity primarily increased antibody levels without substantially altering antibody decay rates. Together, these findings demonstrate robust cellular immune memory to SARS-CoV-2 and its variants for at least 6 months after mRNA vaccination.

引用

页码：1214 / +

页数：41

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