Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)4-catalyzed Knoevenagel reactions

被引：71
|
作者：
Yamashita, K [1 ]
Tanaka, T [1 ]
Hayashi, M [1 ]
机构：
[1] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan
来源：
TETRAHEDRON | 2005年 / 61卷 / 33期
关键词：
D O I：
10.1016/j.tet.2005.06.008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Knoevenagel reactions of aldehydes and ketones with malononitrile, isopropyl cyanoacetate and diisopropyl malonate catalyzed by Ti(O-i-Pr)(4) proceeded smoothly in i-PrOH to give the corresponding reaction products in good to high yield. 3-Substituted coumarins were prepared by the present method. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7981 / 7985
页数：5
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