Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)4-catalyzed Knoevenagel reactions

被引：71

作者：

Yamashita, K ^{[1
]}

Tanaka, T ^{[1
]}

Hayashi, M ^{[1
]}

机构：

[1] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 33期

关键词：

D O I：

10.1016/j.tet.2005.06.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Knoevenagel reactions of aldehydes and ketones with malononitrile, isopropyl cyanoacetate and diisopropyl malonate catalyzed by Ti(O-i-Pr)(4) proceeded smoothly in i-PrOH to give the corresponding reaction products in good to high yield. 3-Substituted coumarins were prepared by the present method. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7981 / 7985

页数：5

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