Anti-HIV-1 inhibitors of various molecules using principles of connectivity

被引：2

作者：

Jalbout, AF ^{[1
]}

Li, XH

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

[2] Dillard Univ, Dept Phys, New Orleans, LA 70112 USA

[3] Wenzhou Normal Coll, Dept Chem, Wenzhou 325027, Zhejiang, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM | 2003年 / 663卷 / 1-3期

关键词：

anti-HIV-1; activities; nonnucleoside reverse transcriptase inhibitors; molecular connectivity index; quantitative structure-activity relationships multiple linear regression analysis;

D O I：

10.1016/S0166-1280(03)00475-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The molecular connectivity index was proved to be one of the most successful and widely used indexes. In this study, we have applied this concept to the analysis of the anti-HIV-1 potencies of TIBO reverse transcriptase inhibitors. Their activities are expressed in terms of certain statistical Oerties of their molecular connectivity index. The results provide insight into some of the factors that promote inhibition. (C) 2003 Published by Elsevier B.V.

引用

页码：19 / 23

页数：5

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