Anti-HIV-1 inhibitors of various molecules using principles of connectivity

被引：2

作者：

Jalbout, AF ^{[1
]}

Li, XH

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

[2] Dillard Univ, Dept Phys, New Orleans, LA 70112 USA

[3] Wenzhou Normal Coll, Dept Chem, Wenzhou 325027, Zhejiang, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM | 2003年 / 663卷 / 1-3期

关键词：

anti-HIV-1; activities; nonnucleoside reverse transcriptase inhibitors; molecular connectivity index; quantitative structure-activity relationships multiple linear regression analysis;

D O I：

10.1016/S0166-1280(03)00475-5

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The molecular connectivity index was proved to be one of the most successful and widely used indexes. In this study, we have applied this concept to the analysis of the anti-HIV-1 potencies of TIBO reverse transcriptase inhibitors. Their activities are expressed in terms of certain statistical Oerties of their molecular connectivity index. The results provide insight into some of the factors that promote inhibition. (C) 2003 Published by Elsevier B.V.

引用

页码：19 / 23

页数：5

共 50 条

[21] Antimicrobial polypeptides are key Anti-HIV-1 effector molecules of cervicovaginal host defense
Cole, Alexander M.
Cole, Amy Liese
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008, 59 (01) : 27 - 34
[22] ANTI-HIV-1 ACTIVITY OF NEW INTEGRASE INHIBITORS IN LYMPHOCYTES AND HUMAN PRIMARY MACROPHAGES
Pollicita, M.
Scopelliti, F.
Silberstein, F. Ceecherini
Armenia, D.
Aquaro, S.
Perno, C. F.
INFECTION, 2009, 37 : 23 - 23
[23] Importance of anti-HIV-1 antibodies - Reply
Parren, PWHI
Sattenau, QJ
Burton, DR
NATURE MEDICINE, 1997, 3 (06) : 591 - 591
[24] Anti-HIV-1 activity of inorganic polyphosphates
Lorenz, B
Leuck, J
Kohl, D
Muller, WEG
Schroder, HC
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1997, 14 (02): : 110 - 118
[25] Anti-HIV-1 activity of calanolides used in combination with other mechanistically diverse inhibitors of HIV-1 replication
Buckheit, RW
Russell, JD
Xu, ZQ
Flavin, M
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 2000, 11 (05): : 321 - 327
[26] ANTI-HIV-1 RIBOZYMES - PROSPECTS AND PROBLEMS
ROSSI, JJ
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (05) : 862 - 862
[27] The anti-HIV-1 activity associated with saliva
Shine, N
Konopka, K
Duzgunes, N
JOURNAL OF DENTAL RESEARCH, 1997, 76 (02) : 634 - 640
[28] ANTI-HIV-1 ACTIVITY OF CURDLAN SULFATE
AOKI, T
KANEKO, Y
TING, RCY
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1993, 6 (06): : 675 - 675
[29] Anti-HIV-1 drugs and endothelial dysfunction
Agrawal, KC
Pradhan, L
Lu, K
Ali, M
Mondal, D
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 38 (05) : 839 - 839
[30] Status of anti-HIV-1 chemotherapy in Japan
Oishi, T
Sugiura, W
Matsuda, M
Abumi, H
Okano, A
Yamada, K
Koike, M
Taki, M
Ishikawa, M
Miura, T
Fukutake, K
Gouchi, K
Ajisawa, A
Iwamoto, A
Hanabusa, H
Mimaya, J
Takamatsu, J
Takata, N
Kakishita, E
Higasa, S
Yoshioka, A
Kashiwagi, S
Shirahata, A
Nagai, Y
JAPANESE JOURNAL OF INFECTIOUS DISEASES, 1999, 52 (02) : 51 - 52

← 1 2 3 4 5 →