Mechanisms for the transition from physiological to pathological cardiac hypertrophy

被引:134
|
作者
Oldfield, Christopher J. [1 ,2 ]
Duhamel, Todd A. [1 ,2 ]
Dhalla, Naranjan S. [2 ,3 ]
机构
[1] Univ Manitoba, Fac Kinesiol & Recreat Management, Winnipeg, MB R3T 2N2, Canada
[2] St Boniface Gen Hosp, Inst Cardiovasc Sci, Albrechtsen Res Ctr, Winnipeg, MB R2H 2A6, Canada
[3] Univ Manitoba, Max Rady Coll Med, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 0J9, Canada
关键词
cardiac hypertrophy; cardiac remodeling; pathological cardiac hypertrophy; physiological cardiac hypertrophy; adaptive cardiac hypertrophy; cardiac contractile function; TUMOR-NECROSIS-FACTOR; ENDOTHELIAL GROWTH-FACTOR; PRESSURE-OVERLOAD HYPERTROPHY; RETICULUM GENE-EXPRESSION; OXIDATIVE STRESS; HEART-FAILURE; SARCOPLASMIC-RETICULUM; ANGIOTENSIN-II; FACTOR-BETA; DIASTOLIC DYSFUNCTION;
D O I
10.1139/cjpp-2019-0566
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The heart is capable of responding to stressful situations by increasing muscle mass, which is broadly defined as cardiac hypertrophy. This phenomenon minimizes ventricular wall stress for the heart undergoing a greater than normal workload. At initial stages, cardiac hypertrophy is associated with normal or enhanced cardiac function and is considered to be adaptive or physiological; however, at later stages, if the stimulus is not removed, it is associated with contractile dysfunction and is termed as pathological cardiac hypertrophy. It is during physiological cardiac hypertrophy where the function of subcellular organelles, including the sarcolemma, sarcoplasmic reticulum, mitochondria, and myofibrils, may be upregulated, while pathological cardiac hypertrophy is associated with downregulation of these subcellular activities. The transition of physiological cardiac hypertrophy to pathological cardiac hypertrophy may be due to the reduction in blood supply to hypertrophied myocardium as a consequence of reduced capillary density. Oxidative stress, inflammatory processes, Ca2+-handling abnormalities, and apoptosis in cardiomyocytes are suggested to play a critical role in the depression of contractile function during the development of pathological hypertrophy.
引用
收藏
页码:74 / 84
页数:11
相关论文
共 50 条
  • [21] Modulation of Impact of Obesity in Pathological and Physiological Cardiac Hypertrophy by Orlistat
    Singh, Randhir
    Singh, Manjeet
    Krishan, Pawan
    [J]. LATIN AMERICAN JOURNAL OF PHARMACY, 2010, 29 (05): : 754 - 762
  • [22] Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy
    Abel, E. Dale
    Doenst, Torsten
    [J]. CARDIOVASCULAR RESEARCH, 2011, 90 (02) : 234 - 242
  • [23] Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy
    Wilkins, BJ
    Dai, YS
    Bueno, OF
    Parsons, SA
    Xu, J
    Plank, DM
    Jones, F
    Kimball, TR
    Molkentin, JD
    [J]. CIRCULATION RESEARCH, 2004, 94 (01) : 110 - 118
  • [24] OVARIECTOMY PREVENTS PHYSIOLOGICAL AND POTENTIATES PATHOLOGICAL CARDIAC-HYPERTROPHY
    MALHOTRA, A
    BUTTRICK, PM
    SCHEUER, J
    [J]. CIRCULATION, 1987, 76 (04) : 235 - 235
  • [25] Physiological and pathological gestational cardiac hypertrophy: what can we learn from rodents?
    Sampaolesi, Maurilio
    Van Calsteren, Kristel
    [J]. CARDIOVASCULAR RESEARCH, 2017, 113 (13) : 1533 - 1535
  • [26] Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy
    Kemi, Ole Johan
    Ceci, Marcello
    Wisloff, Ulrik
    Grimaldi, Serena
    Gallo, Paolo
    Smith, Godfrey L.
    Condorelli, Gianluigi
    Ellingsen, Oyvind
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2008, 214 (02) : 316 - 321
  • [27] Impaired force-frequency relations in patients with hypertensive left ventricular hypertrophy - A possible physiological marker of the transition from physiological to pathological hypertrophy
    Inagaki, M
    Yokota, M
    Izawa, H
    Ishiki, R
    Nagata, K
    Iwase, M
    Yamada, Y
    Koide, M
    Sobue, T
    [J]. CIRCULATION, 1999, 99 (14) : 1822 - 1830
  • [28] Mitochondrial biogenesis and energy metabolism in cardiac pathological aversus physiological hypertrophy
    Rimbaud, S.
    Barneoud, L.
    Sanchez, H.
    Fortin, D.
    Veksler, V.
    Bigard, X.
    Ventura-Clapier, R.
    Garnier, A.
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 44 (04) : 813 - 813
  • [29] Models for VEGF-B induced physiological and pathological cardiac hypertrophy
    Rasanen, M. O. H.
    Hemanthakumar, K. Amudhala
    Paech, J. B.
    Robciuc, M. R.
    Ramanujam, D.
    Lahteenvuo, J. B.
    Engelhardt, S.
    Kivela, R.
    Alitalo, K.
    [J]. CARDIOVASCULAR RESEARCH, 2018, 114 : S60 - S60
  • [30] Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy
    Kinugawa, K
    Yonekura, K
    Ribeiro, RCJ
    Eto, Y
    Aoyagi, T
    Baxter, JD
    Camacho, SA
    Bristow, MR
    Long, CS
    Simpson, PC
    [J]. CIRCULATION RESEARCH, 2001, 89 (07) : 591 - 598