Collagen-based biomaterials for ibuprofen delivery

被引：24

作者：

Tihan, Gratiela Teodora ^{[1
]}

Rau, Ileana ^{[1
]}

Zgarian, Roxana Gabriela ^{[1
]}

Ghica, Mihaela Violeta ^{[2
]}

机构：

[1] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Gen Chem, Bucharest, Romania

[2] Carol Davila Univ Med & Pharm, Fac Pharm, Phys & Colloidal Chem Dept, Bucharest, Romania

来源：

COMPTES RENDUS CHIMIE | 2016年 / 19卷 / 03期

关键词：

Collagen sponges; FT-IR analysis; Ibuprofen; Kinetic profile; Dentistry; DRUG-DELIVERY;

D O I：

10.1016/j.crci.2015.09.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug delivery systems based on collagen sponges have increasingly become interesting materials for different medical applications. In this paper we present the obtaining, characterization and in vitro release of ibuprofen from collagen-based biomaterials in the form of sponges. The structural and morphological characteristics of these materials were investigated by infrared spectroscopy (FT-IR) and water uptake tests. Collagenase degradation, anti-inflammatory drug release and the kinetic mechanism are also discussed. The results obtained suggest that these new systems based on collagen have good potential for sustained release of analgesic and anti-inflammatory agents such as ibuprofen and the combination of collagen and ibuprofen as a sponge is a promising therapeutic method for the treatment of dental problems. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：390 / 394

页数：5

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