Prevalence and correlation of conventional and lupus-specific risk factors for cardiovascular disease in Chinese systemic lupus erythematosus patients

被引:30
|
作者
Yang, L. [1 ]
Tao, J. [1 ]
Tang, X. [2 ]
Wang, Y. [1 ]
He, X. [1 ]
Xu, G. [1 ]
Ren, Y. [1 ]
Tu, Y. [1 ]
机构
[1] Huazhong Univ Sci & Technol, Affiliated Union Hosp, Tongji Med Coll, Dept Dermatol, Wuhan 430074, Hubei Province, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Div Rheumatol, Hong Kong, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
CORONARY-HEART-DISEASE; ACCELERATED ATHEROSCLEROSIS; ARTERY; WOMEN; STROKE;
D O I
10.1111/j.1468-3083.2011.04211.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background It has become clear that the morbidity and mortality of patients with lupus and cardiovascular disease (CVD) have substantially increased. Therefore, we designed a retrospective casecontrol study to assess the prevalence of traditional and lupus-specific risk factors for CVD in Chinese systemic lupus erythematosus (SLE) patients. Objective To identify the prevalence and correlation of conventional and lupus-specific risk factors for CVD in Chinese SLE patients. Methods One hundred and thirty-nine patients with SLE were enrolled in the study. They were compared with 139 age and gender-matched controls, who had no history of SLE or CVD. Among 139 SLE patients, there were 38 with CVD. We compared them with 38 SLE patients without CVD, matching for disease duration and age. Data regarding classic and lupus-specific risk factors were assessed between the two groups. Results Hypertension, serum creatinine and diabetes mellitus were more prevalent among SLE than the controls (P < 0.05). The patients with SLE were more likely to have elevated total, low-density lipoprotein cholesterol and triglyceride levels than the controls (P < 0.001). However, high-density lipoprotein levels in SLE patients were lower than that in controls (P = 0.019). After being compared with SLE patients without CVD, the patients with both SLE and CVD were more likely to have elevated serum creatinine, proteinuria, the presence of anti-Sm antibody and decreased complement 4 (C4) levels (P < 0.05). Moreover, the patients with both diseases were less likely to be treated with hydroxychloroquine (P < 0.05). In multivariable analysis, elevated serum creatinine, proteinuria, decreased C4 levels, the presence of anti-Sm antibody and the lack of using hydroxychloroquine were independent risk factors for CVD (P < 0.05). Conclusions We are able to identify some conventional and lupus-specific risk factors for CVD in Chinese SLE patients.
引用
收藏
页码:95 / 101
页数:7
相关论文
共 50 条
  • [21] What do lupus specialists believe about managing conventional cardiovascular risk factors in patients with systemic lupus erythematosus?
    Rahman, A.
    Bessant, R.
    Isenberg, D. A.
    LUPUS, 2006, 15 (10) : 697 - 699
  • [22] Cardiovascular risk in patients with systemic lupus erythematosus
    Dobrota, V. Dermanovic
    Prkacin, I.
    Dobrota, S.
    Hrabac, P.
    Lukinovic-Skudar, V.
    CEREBROVASCULAR DISEASES, 2015, 39 : 35 - 35
  • [23] High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors
    Chung, Cecilia P.
    Avalos, Ingrid
    Oeser, Annette
    Gebretsadik, Tebeb
    Shintani, Ayumi
    Raggi, Paolo
    Stein, C. Michael
    ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (02) : 208 - 214
  • [24] Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry: Prevalence and Risk Factors of Pulmonary Arterial Hypertension and Interstitial Lung Disease in Chinese Patients with Systemic Lupus Erythematosus.
    Wang, Qian
    Li, Mengtao
    Zhao, Jiuliang
    Zeng, Xiaofeng
    ARTHRITIS AND RHEUMATISM, 2011, 63 (10): : S232 - S232
  • [25] Lupus-specific risk factors are associated with progression of carotid intima-media thickness and plaque in women with systemic lupus erythematosus
    Thompson, T
    Sutton-Tyrrell, K
    Brockwell, S
    Wildman, RP
    Kazienko, B
    Fitzgerald, S
    Manzi, S
    CIRCULATION, 2006, 113 (08) : E359 - E359
  • [26] Peripheral Arterial Disease in Systemic Lupus Erythematosus: Prevalence and Risk Factors
    Erdozain, Jose Gabriel
    Villar, Irama
    Nieto, Javier
    Ruiz-Irastorza, Guillermo
    JOURNAL OF RHEUMATOLOGY, 2014, 41 (02) : 310 - 317
  • [27] The Effect of Weight Loss on Cardiovascular Disease Risk Factors in Patients With Systemic Lupus Erythematosus
    Mishler, Anne E.
    Rickman, Amy D.
    Shah, Nehal R.
    Wilson, Nicole
    Kao, Amy H.
    Gibbs, Bethany Barone
    Garcia, David O.
    OBESITY, 2011, 19 : S96 - S97
  • [28] RISK FACTORS OF HEART DISEASE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
    Ganiyeva, N. A.
    Kasymova, M. B.
    Ziyayeva, F. K.
    Djurayeva, E. R.
    Berdiyeva, D. U.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 1074 - 1075
  • [29] Systemic lupus erythematosus: managing cardiovascular risk factors
    Rahman, Anisur
    LANCET RHEUMATOLOGY, 2024, 6 (07): : e415 - e416
  • [30] RELATIONSHIP OF HOMOCYSTEINE WITH CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
    Navarro, Maria
    Pais, Fanny
    Lopez, Wilfredo
    Cabello, Roman
    Salazar, Milay
    Zerpa, Anaiz
    COMUNIDAD Y SALUD, 2014, 12 (02) : 51 - 61