RELATIONSHIP OF HOMOCYSTEINE WITH CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

The cardiovascular complications are a leading cause of death in systemic lupus erythematosus (SLE), there is an association between hyperhomocysteinemia and the risk of cardiovascular disease. The objective was to establish the relationship between hcys with classic cardiovascular risk factors in patients with SLE and apparently healthy individuals (control group, CTR). SLE patients (female n = 19 and female n = 1) and the CTR group (female n = 14 and female n = 6) were determined: blood pressure, body mass index (BMI), waist / hip (ICC), blood glucose, lipid profile (cholesterol, HDL-c, LDL-c, VLDL-c and triglycerides) and hcys. Both groups had blood pressure, ICC (0.81 +/- 0.06 vs 0.85 +/- 0.07) and BMI (26.05 +/- 5.33 vs 25.35 +/- 3.66 kg/m2 kg/m2), BG (LES, 76.7 +/- 19.81 mg / dL vs 75.8 +/- 11.70 mg / dL), cholesterol (170.3 +/- 58.1 vs 167.40 +/- 39.4 mg / dL), triglycerides (104.9 +/- 55.4 vs 115.1 +/- 63.6 mg / dL, P = 0.593), HDL-c (41.45 +/- 6.54 mg / dL vs 42.35 +/- 9.4 mg / dL), LDL-c (107.9 +/- 55.1 vs 101.7 +/- 34.3 mg / dL), VLDL-c (20.9 +/- 11.02 vs 23.3 +/- 12.7 mg / dL) and Hcys (LES, 12.73 +/- 4.91 mmol / L vs 16.08 +/- 8.61 CTR mol / L) were within the reference values without statistically significant differences (P> 0.05). A correlation between Hcys, total cholesterol and LDL in SLE was found. It can be concluded that changes in total cholesterol and LDL is a direct consequence of Hcys.