Role of TREM-1 in cardiovascular diseases

被引：0
|
作者：
Vandestienne, Marie [1 ]
Joffre, Jeremie [2 ]
Lemarie, Jeremie [1 ,3 ]
Ait-Oufella, Hafid [1 ,2 ]
机构：
[1] Univ Paris, INSERM, U970, PARCC Paris Cardiovasc Res Ctr, Paris, France
[2] Sorbonne Univ, Hop St Antoine, AP HP, Serv Med Intens Reanimat, Paris, France
[3] CHU Nantes, Serv Med Intens Reanimat, Nantes, France
来源：
M S-MEDECINE SCIENCES | 2022年 / 38卷 / 01期
关键词：
PHARMACOLOGICAL INHIBITION; INFLAMMATORY RESPONSE; RECEPTOR; INJURY; ATHEROSCLEROSIS; PATHOGENESIS; NEUTROPHILS; MECHANISMS; LIMITS;
D O I：
10.1051/medsci/2021242
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The innate immune system plays a crucial role in cardiovascular disease initiation, progression and complications. TREM-1, a receptor mainly expressed by myeloid cells, orchestrates inflammatory responses and amplifies cytokine and chemokine production as well as oxidative burst. Recent experimental studies have demonstrated that TREM-1 blockade is protective, limiting atherosclerosis and abdominal aortic aneurysm development, as well as adverse tissue remodeling after cardiac or cerebral ischemic injuries. Plasma soluble TR epsilon M-1 level is a promising biomarker in patients with cardiovascular diseases for risk stratification, paving the way for personalized immune-modulatory approaches.
引用
收藏
页码：32 / 37
页数：6
相关论文
共 50 条
  • [31] TREM-1 Contributes to Inflammation in IgA Nephropathy
    Zhao, Yan-Feng
    Zhu, Li
    Liu, Li-Jun
    Shi, Su-Fang
    Lv, Ji-Cheng
    Zhang, Hong
    KIDNEY DISEASES, 2018, 4 (01) : 29 - 36
  • [32] TREM-1 stimulation ameliorates colitis in mice
    Ma, H. W.
    Che, X.
    Seo, D. H.
    Kim, J. H.
    Kim, D. H.
    Kim, T. I.
    Kim, W. H.
    Kim, S. W.
    Cheon, J. H.
    JOURNAL OF CROHNS & COLITIS, 2016, 10 : S124 - S124
  • [33] The role of TREM-1 in the severity of human cutaneous leishmaniasis through a translational study
    Ampuero, M.
    Nunes, S.
    Feijo, D.
    Khouri, R.
    Boaventura, V
    Barral, A.
    Brodskyn, C.
    Tavares, N.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 1051 - 1051
  • [34] Soluble TREM-1 and the diagnosis of pneumonia -: Reply
    Gibot, S
    Levy, B
    Béné, MC
    NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (18): : 1905 - 1905
  • [35] TREM-1, a negative regulator of human osteoclastogenesis
    Lee, Bitnara
    Kim, Jong-Heon
    Jung, Jun Ha
    Kim, Tae-Hwan
    Ji, Jong Dae
    IMMUNOLOGY LETTERS, 2016, 171 : 50 - 59
  • [36] Association of salivary TREM-1 and PGLYRP1 inflammatory markers with non-communicable diseases
    Silbereisen, Angelika
    Lira-Junior, Ronaldo
    Akerman, Sigvard
    Klinge, Bjorn
    Bostrom, Elisabeth A. A.
    Bostanci, Nagihan
    JOURNAL OF CLINICAL PERIODONTOLOGY, 2023, 50 (11) : 1467 - 1475
  • [37] TREM-1 as a Potential Therapeutic Target in Psoriasis
    Hyder, Luke A.
    Gonzalez, Juana
    Harden, Jamie L.
    Johnson-Huang, Leanne M.
    Zaba, Lisa C.
    Pierson, Katherine C.
    Eungdamrong, Narat J.
    Lentini, Tim
    Gulati, Nicholas
    Fuentes-Duculan, Judilyn
    Suarez-Farinas, Mayte
    Lowes, Michelle A.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 (07) : 1742 - 1751
  • [38] Opposite effects of TREM-1 and TREM-2 during influenza infection
    Weiss, G.
    Lai, C.
    Xin, G.
    Hussell, T.
    IMMUNOLOGY, 2014, 143 : 107 - 107
  • [39] TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives
    Sigalov, Alexander B.
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [40] Differential Expression Of TREM-1 In Myelogenous Leukemia Cells
    Li, Huiyu
    Li, Wenying
    Yi, Xiaoling
    Huang, Shiang
    Liu, Wei
    Jiang, Li
    Yang, Chao
    Li, Juan
    BLOOD, 2013, 122 (21)
12345