Role of TREM-1 in cardiovascular diseases

被引：0
|
作者：
Vandestienne, Marie [1 ]
Joffre, Jeremie [2 ]
Lemarie, Jeremie [1 ,3 ]
Ait-Oufella, Hafid [1 ,2 ]
机构：
[1] Univ Paris, INSERM, U970, PARCC Paris Cardiovasc Res Ctr, Paris, France
[2] Sorbonne Univ, Hop St Antoine, AP HP, Serv Med Intens Reanimat, Paris, France
[3] CHU Nantes, Serv Med Intens Reanimat, Nantes, France
来源：
M S-MEDECINE SCIENCES | 2022年 / 38卷 / 01期
关键词：
PHARMACOLOGICAL INHIBITION; INFLAMMATORY RESPONSE; RECEPTOR; INJURY; ATHEROSCLEROSIS; PATHOGENESIS; NEUTROPHILS; MECHANISMS; LIMITS;
D O I：
10.1051/medsci/2021242
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The innate immune system plays a crucial role in cardiovascular disease initiation, progression and complications. TREM-1, a receptor mainly expressed by myeloid cells, orchestrates inflammatory responses and amplifies cytokine and chemokine production as well as oxidative burst. Recent experimental studies have demonstrated that TREM-1 blockade is protective, limiting atherosclerosis and abdominal aortic aneurysm development, as well as adverse tissue remodeling after cardiac or cerebral ischemic injuries. Plasma soluble TR epsilon M-1 level is a promising biomarker in patients with cardiovascular diseases for risk stratification, paving the way for personalized immune-modulatory approaches.
引用
收藏
页码：32 / 37
页数：6
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