Role of TREM-1 in cardiovascular diseases

被引：0
|
作者：
Vandestienne, Marie [1 ]
Joffre, Jeremie [2 ]
Lemarie, Jeremie [1 ,3 ]
Ait-Oufella, Hafid [1 ,2 ]
机构：
[1] Univ Paris, INSERM, U970, PARCC Paris Cardiovasc Res Ctr, Paris, France
[2] Sorbonne Univ, Hop St Antoine, AP HP, Serv Med Intens Reanimat, Paris, France
[3] CHU Nantes, Serv Med Intens Reanimat, Nantes, France
来源：
M S-MEDECINE SCIENCES | 2022年 / 38卷 / 01期
关键词：
PHARMACOLOGICAL INHIBITION; INFLAMMATORY RESPONSE; RECEPTOR; INJURY; ATHEROSCLEROSIS; PATHOGENESIS; NEUTROPHILS; MECHANISMS; LIMITS;
D O I：
10.1051/medsci/2021242
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The innate immune system plays a crucial role in cardiovascular disease initiation, progression and complications. TREM-1, a receptor mainly expressed by myeloid cells, orchestrates inflammatory responses and amplifies cytokine and chemokine production as well as oxidative burst. Recent experimental studies have demonstrated that TREM-1 blockade is protective, limiting atherosclerosis and abdominal aortic aneurysm development, as well as adverse tissue remodeling after cardiac or cerebral ischemic injuries. Plasma soluble TR epsilon M-1 level is a promising biomarker in patients with cardiovascular diseases for risk stratification, paving the way for personalized immune-modulatory approaches.
引用
收藏
页码：32 / 37
页数：6
相关论文
共 50 条
  • [1] TREM-1; Is It a Pivotal Target for Cardiovascular Diseases?
    Kouassi, Kouassi T.
    Gunasekar, Palanikumar
    Agrawal, Devendra K.
    Jadhav, Gopal P.
    JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, 2018, 5 (03)
  • [2] Role of TREM-1 in PMN transmigration
    Reaves, Titus A.
    Parent, Lindsey M.
    GASTROENTEROLOGY, 2006, 130 (04) : A557 - A557
  • [3] Role of TREM-1 in pulmonary tuberculosis patients-analysis of serum soluble TREM-1 levels
    Feng, Jia-Yih
    Su, Wei-Juin
    Pan, Sheng-Wei
    Yeh, Yi-Chen
    Lin, Yung-Yang
    Chen, Nien-Jung
    SCIENTIFIC REPORTS, 2018, 8
  • [4] Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels
    Jia-Yih Feng
    Wei-Juin Su
    Sheng-Wei Pan
    Yi-Chen Yeh
    Yung-Yang Lin
    Nien-Jung Chen
    Scientific Reports, 8
  • [5] TREM-1 in sepsis
    Cohen, J
    LANCET, 2001, 358 (9284): : 776 - 778
  • [6] Therapeutic Potential of Targeting TREM-1 in Inflammatory Diseases and Cancer
    Bosco, Maria Carla
    Raggi, Federica
    Varesio, Luigi
    CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (41) : 6209 - 6233
  • [7] The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
    Chunyan Zhang
    Xugang Kan
    Baole Zhang
    Haibo Ni
    Jianfeng Shao
    Molecular Brain, 15
  • [8] Role of TREM-1 in endothelial dysfunction during experimental sepsis
    A Boufenzer
    N Sennoun
    Y Bouazza
    M Derive
    PE Bollaert
    S Gibot
    Critical Care, 16 (Suppl 3):
  • [9] The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
    Zhang, Chunyan
    Kan, Xugang
    Zhang, Baole
    Ni, Haibo
    Shao, Jianfeng
    MOLECULAR BRAIN, 2022, 15 (01)
  • [10] Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium:: implication for a role of TREM-1 in Helicobacter pylori infection
    Schmausser, B.
    Endrich, S.
    Beier, D.
    Moran, A. P.
    Burek, C. J.
    Rosenwald, A.
    Rieckmann, P.
    Mueller-Hermelink, H. -K.
    Eck, M.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2008, 152 (01): : 88 - 94
12345