Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies

被引：9
|
作者：
Ramaswamy, Kavitha [1 ]
Rashid, Mariya [2 ,3 ]
Ramasamy, Selvarajan [4 ]
Jayavelu, Tamilselvan [1 ]
Venkataraman, Sangita [1 ]
机构：
[1] Anna Univ, Dept Biotechnol, Sardar Patel Rd, Chennai 600025, Tamil Nadu, India
[2] Natl Def Med Ctr, Taiwan Int Grad Program, Mol Cell Biol, Taipei 115, Taiwan
[3] Acad Sinica, Taipei 115, Taiwan
[4] Natl Res Ctr Banana, Somarasempettai Thogaimalai Rd, Podavur 639103, Tamil Nadu, India
来源：
VIRUSES-BASEL | 2022年 / 14卷 / 10期
关键词：
replication; polymerase; cofactors; structure; RNA viruses; inhibitors; SARS-COV-2; REPLICATION; INFLUENZA POLYMERASE; COMPLEX REVEALS; L PROTEIN; TRANSCRIPTION; VIRUS; MECHANISM; ACTIVATION; BINDING; SURFACE;
D O I：
10.3390/v14102200
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors.
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页数：39
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