Regioselective Oxidative Chlorination of Arenols Using NaCl and Oxone

被引：22

作者：

Uyanik, Muhammet ^{[1
]}

Sahara, Naoto ^{[1
]}

Ishihara, Kazuaki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648603, Japan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 01期

关键词：

Chlorination; Dearomatization; Oxidation; Phenols; Chemoselectivity; Regioselectivity; CATALYTIC ASYMMETRIC DEAROMATIZATION; SODIUM-HYPOCHLORITE; IPSO-CHLORINATION; METHYL-ETHER; PHENOL; HALOGENATION; CONVENIENT; POTASSIUM; CHLORIDE; CARBON;

D O I：

10.1002/ejoc.201801063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a practical and environmentally benign method for the chlorinative dearomatization of arenols using transient electrophilic chlorinating species generated in situ from inexpensive sodium chloride and Oxone as a Cl source and oxidant, respectively, under mild conditions. Moreover, the regioselective chlorination or chlorinative dearomatization of 1-naphthols was also achieved by changing the reaction conditions.

引用

页码：27 / 31

页数：5

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