Regioselective Oxidative Chlorination of Arenols Using NaCl and Oxone

被引：22
|
作者：
Uyanik, Muhammet [1 ]
Sahara, Naoto [1 ]
Ishihara, Kazuaki [1 ]
机构：
[1] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648603, Japan
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 01期
关键词：
Chlorination; Dearomatization; Oxidation; Phenols; Chemoselectivity; Regioselectivity; CATALYTIC ASYMMETRIC DEAROMATIZATION; SODIUM-HYPOCHLORITE; IPSO-CHLORINATION; METHYL-ETHER; PHENOL; HALOGENATION; CONVENIENT; POTASSIUM; CHLORIDE; CARBON;
D O I：
10.1002/ejoc.201801063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We developed a practical and environmentally benign method for the chlorinative dearomatization of arenols using transient electrophilic chlorinating species generated in situ from inexpensive sodium chloride and Oxone as a Cl source and oxidant, respectively, under mild conditions. Moreover, the regioselective chlorination or chlorinative dearomatization of 1-naphthols was also achieved by changing the reaction conditions.
引用
收藏
页码：27 / 31
页数：5
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