In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

被引：61

作者：

Feldman, KS

Sahasrabudhe, K

Lawlor, MD

Wilson, SL

Lang, CH

Scheuchenzuber, WJ

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

[2] Penn State Univ, Dept Life Sci Consortium, University Pk, PA 16802 USA

[3] Penn State Univ, Milton S Hershey Med Ctr, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(01)00332-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The naturally occurring gallotannin beta -D-pentagalloylglucose (beta -PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at similar to 5 muM concentration. A qualitatively similar but less pronounced effect (similar to 50% decrease) was observed in the serum of rats dosed with both LPS and beta -PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1813 / 1815

页数：3

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