In vitro and in vivo inhibition of LPS-stimulated tumor necrosis factor-α secretion by the gallotannin β-D-pentagalloylglucose

被引：61
|
作者：
Feldman, KS
Sahasrabudhe, K
Lawlor, MD
Wilson, SL
Lang, CH
Scheuchenzuber, WJ
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Life Sci Consortium, University Pk, PA 16802 USA
[3] Penn State Univ, Milton S Hershey Med Ctr, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期
关键词：
D O I：
10.1016/S0960-894X(01)00332-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The naturally occurring gallotannin beta -D-pentagalloylglucose (beta -PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at similar to 5 muM concentration. A qualitatively similar but less pronounced effect (similar to 50% decrease) was observed in the serum of rats dosed with both LPS and beta -PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1813 / 1815
页数：3
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