Acyl flavone and lignan glucosides from Leontopodium leontopodioides

Two new acyl flavone glucosides, luteolin-4 '-O-(6-p-hydroxybenzoyl)-beta-D-glucopyranoside (leontopodioside A, 1) and luteolin-4 '-O-[ 6-(2-methylbutyryl)]-beta-D-glucopyranoside (leontopodioside B, 2), and a new acyl lignan glucoside, lariciresinol-9-angeloyl-4-O-beta-D-glucopyranoside (leontopodioside C, 3) were isolated from the whole plants of Leontopodium leontopodioides (Asteraceae). Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 exhibited alpha-glucosidase inhibitory activity with the half maximal inhibitory concentration (IC50) values of 55.6, 39.7, and 474.9 mu M, respectively, in comparison with acarbose (626.3 mu M). (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.