A new component test suited for quasi-static and dynamic testing of flow-drill screw connections is presented. The component specimen was made of two different aluminium alloys, and included connections with two material combinations. Large-scale finite element simulations were carried out of each test, in which the connections were modelled with a constraint-based macroscopic model. An improvement of the connection modelling technique is presented. The model was calibrated to cross tension, cross mixed and single lap joint tests, and validated with peeling and the component tests.