Hepatocyte growth factor promotes migration of human myeloma cells

被引：39

作者：

Holt, Randi Utne ^{[1
,2
]}

Fagerli, Unn-Merete ^{[1
,3
]}

Baykov, Vadim ^{[1
]}

Ro, Torstein Baade ^{[1
]}

Hov, Hakon ^{[1
]}

Waage, Anders ^{[1
,4
]}

Sundan, Anders ^{[1
]}

Borset, Magne ^{[1
,5
]}

机构：

[1] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Trondheim, Norway

[2] Sor Trondelag Univ Coll, Fac Technol, Trondheim, Norway

[3] St Olavs Hosp, Dept Oncol, Trondheim, Norway

[4] St Olavs Hosp, Dept Hematol, Trondheim, Norway

[5] St Olavs Hosp, Dept Immunol & Transfus Med, Trondheim, Norway

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 04期

关键词：

myeloma; cell migration; hepatocyte growth factor; stromal cell-derived growth factor-1;

D O I：

10.3324/haematol.11867

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events. We studied migration in a Transwell two-chamber assay and tested the motogenic effect of various cytokines. In addition to insulin-like growth factor-1 and stromal cell-derived growth factor-1 alpha, previously known as chemoattractants for myeloma cells, we identified hepatocyte growth factor as a potent attractant for myeloma cells. Hepatocyte growth factor-mediated migration was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins.

引用

页码：619 / 622

页数：4

共 50 条

[31] Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma
Iwasaki, T
Hamano, T
Ogata, A
Hashimoto, N
Kitano, M
Kakishita, E
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 116 (04) : 796 - 802
[32] Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma In situ
Jedeszko, Christopher
Victor, Bernadette C.
Podgorski, Izabela
Sloane, Bonnie F.
CANCER RESEARCH, 2009, 69 (23) : 9148 - 9155
[33] Hepatocyte growth factor (HGF) promotes cell survival in corneal epithelial cells.
Kakazu, AH
Chandrasekher, G
Bazan, HEP
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U359 - U359
[34] Hepatocyte growth factor promotes cell survival by phosphorylation of BAD in gastric cancer cells
Lee, Kyung Hee
Choi, Eun Young
Kim, Min Kyoung
Hyun, Myung Soo
Eun, Jong Ryul
Jang, Byung Ik
Kim, Tae Nyeun
Kim, Sang Woon
Song, Sun Kyo
Kim, Jung Hye
Kim, Jae-Ryong
ONCOLOGY RESEARCH, 2008, 17 (01) : 23 - 32
[35] Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: A prognostic marker of human esophageal squamous cell carcinomas
Ren, Y
Cao, B
Law, S
Xie, Y
Lee, PY
Cheung, L
Chen, YX
Huang, X
Chan, HM
Zhao, P
Luk, J
Vande Woude, G
Wong, J
CLINICAL CANCER RESEARCH, 2005, 11 (17) : 6190 - 6197
[36] Hepatocyte growth factor enhances MMP activity in human endothelial cells
Wang, H
Keiser, JA
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 272 (03) : 900 - 905
[37] The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells
Molnarfi, Nicolas
Benkhoucha, Mandia
Juillard, Catherine
Bjarnadottir, Kristbjoerg
Lalive, Patrice H.
JOURNAL OF NEUROIMMUNOLOGY, 2014, 267 (1-2) : 105 - 110
[38] Evidence for a functional Hepatocyte Growth Factor receptor in human mesangial cells
Kallincos, NC
Pollard, AN
Couper, JJ
REGULATORY PEPTIDES, 1998, 74 (2-3) : 137 - 142
[39] Basic fibroblast growth factor stimulates hepatocyte growth factor scatter factor secretion by human mesenchymal cells
Roletto, F
Galvani, AP
Cristiani, C
Valsasina, B
Landonio, A
Bertolero, F
JOURNAL OF CELLULAR PHYSIOLOGY, 1996, 166 (01) : 105 - 111
[40] Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells
Duan, HF
Wu, CT
Lu, Y
Wang, H
Liu, HJ
Zhang, QW
Jia, XX
Lu, ZZ
Wang, LS
EXPERIMENTAL CELL RESEARCH, 2004, 298 (02) : 593 - 601

← 1 2 3 4 5 →