Hepatocyte growth factor promotes migration of human myeloma cells

被引：39

作者：

Holt, Randi Utne ^{[1
,2
]}

Fagerli, Unn-Merete ^{[1
,3
]}

Baykov, Vadim ^{[1
]}

Ro, Torstein Baade ^{[1
]}

Hov, Hakon ^{[1
]}

Waage, Anders ^{[1
,4
]}

Sundan, Anders ^{[1
]}

Borset, Magne ^{[1
,5
]}

机构：

[1] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Trondheim, Norway

[2] Sor Trondelag Univ Coll, Fac Technol, Trondheim, Norway

[3] St Olavs Hosp, Dept Oncol, Trondheim, Norway

[4] St Olavs Hosp, Dept Hematol, Trondheim, Norway

[5] St Olavs Hosp, Dept Immunol & Transfus Med, Trondheim, Norway

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 04期

关键词：

myeloma; cell migration; hepatocyte growth factor; stromal cell-derived growth factor-1;

D O I：

10.3324/haematol.11867

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events. We studied migration in a Transwell two-chamber assay and tested the motogenic effect of various cytokines. In addition to insulin-like growth factor-1 and stromal cell-derived growth factor-1 alpha, previously known as chemoattractants for myeloma cells, we identified hepatocyte growth factor as a potent attractant for myeloma cells. Hepatocyte growth factor-mediated migration was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins.

引用

页码：619 / 622

页数：4

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