Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process

被引：3
|
作者：
Amstalden, Maria-Cecilia Krahenbuehl [1 ,2 ]
Oliveira, Jose Diogo [1 ]
Strauss, Mathias [3 ,4 ]
Mazali, Italo Odone [4 ]
Machado, Daisy [1 ]
Theisen, Thais Holtz [1 ]
Lancellotti, Marcelo [1 ,2 ]
机构：
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, Brazil
[3] Natl Ctr Res Energy & Mat, Brazilian Nanotechnol Natl Lab, Campinas, SP, Brazil
[4] Univ Estadual Campinas, Inst Chem, Funct Mat Lab, Campinas, SP, Brazil
来源：
FOLIA MICROBIOLOGICA | 2019年 / 64卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
RESPIRATORY-INFECTIONS; DRUG-DELIVERY; AIR-POLLUTION; NANOPARTICLES; COMPETENCE; EXPOSURE;
D O I：
10.1007/s12223-018-0631-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360luxS). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 +/- 0.04) and SBA-16 (ratio 2.18 +/- 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics.
引用
收藏
页码：127 / 132
页数：6
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