Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma

Purpose: To evaluate the ability of spectral domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness (RNFLT) parameters to distinguish normal eyes from those with early glaucoma in Asian Indian eyes. Design: Observational cross-sectional study. Materials and Methods: One hundred and seventy eight eyes (83 glaucoma patients and 95 age matched healthy subjects) of subjects more than 40 years of age were included in the study. All subjects underwent RNFLT measurement with spectral OCT/scanning laser ophthalmoscope (SLO) aft er dilatation. Sensitivity, specificity and area under the receiving operating characteristic curve (AROC) were calculated for various OCT peripapillary RNFL parameters. Results: The mean RNFLT in healthy subjects and patients with early glaucoma were 105.7 +/- 5.1 mu m and 90.7 +/- 7.5 mu m, respectively. The largest AROC was found for 12 o'clock-hour (0.98), average (0.96) and superior quadrant RNFLT (0.9). When target specificity was set at >= 90% and >= 80%, the parameters with highest sensitivity were 12 o'clock -hour (91.6%), average RNFLT (85.3%) and 12 o'clock-hour (96.8 %), average RNFLT (94.7%) respectively. Conclusion: Our study showed good ability of spectral OCT/SLO to differentiate normal eyes from patients with early glaucoma and hence it may serve as an useful adjunct for early diagnosis of glaucoma.