Cadinane sesquiterpenes from Curcuma phaeocaulis with their inhibitory activities on nitric oxide production in RAW 264.7 cells

被引：19
|
作者：
Ma, Jianghao [1 ]
Wang, Ying [1 ]
Liu, Yue [1 ]
Gao, Suyu [1 ]
Ding, Liqin [2 ]
Zhao, Feng [3 ]
Chen, Lixia [1 ]
Qiu, Feng [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Dept Nat Prod Chem,Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
来源：
FITOTERAPIA | 2015年 / 103卷
基金：
中国国家自然科学基金;
关键词：
Curcuma phaeocaulis; Cadinane; Sesquiterpenes; Nitric oxide; Biogenetic pathway; GUAIANE-TYPE SESQUITERPENES; PARVIFLORENE-A; WENYUJIN; DIARYLHEPTANOIDS; KWANGSIENSIS; MACROPHAGES; EXTRACTS; RHIZOMES; LONGA;
D O I：
10.1016/j.fitote.2015.03.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new cadinane-type sesquiterpenes named phacadinanes A-D (1-4) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were elucidated by 1D and 2D NMR, as well as accurate mass measurements. Compound 4 was the first example of a rare 4,5-seco-cadinane sesquiterpene isolated from the Zingiberaceae family. Furthermore, inhibitory effects of the isolated compounds on nitric oxide production in LPS-activated macrophages were evaluated. Compounds 1 and 2 showed strong inhibitory activities on NO production with IC50 values of 3.88 +/- 058 and 225 +/- 0.71 mu M, respectively. A possible biogenetic pathway for 4,5-seco-cadinane sesquiterpene (4) was postulated. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：90 / 96
页数：7
相关论文
共 50 条
  • [41] Cadinane sesquiterpenoids from the fungus Antrodiella albocinnamomea and their inhibitory activity against nitric oxide production
    Yu, Wei-Wei
    Ma, Jin-Tao
    He, Juan
    Li, Zheng-Hui
    Liu, Ji-Kai
    Feng, Tao
    PHYTOCHEMISTRY, 2022, 196
  • [42] Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells
    Huang, YC
    Guh, JH
    Cheng, ZJ
    Chang, YL
    Hwang, TL
    Lin, CN
    Teng, CM
    LIFE SCIENCES, 2001, 68 (21) : 2435 - 2447
  • [43] (+)/(−)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors
    Gui-yang Xia
    De-juan Sun
    Jiang-hao Ma
    Yue Liu
    Feng Zhao
    Paul Owusu Donkor
    Li-qin Ding
    Li-xia Chen
    Feng Qiu
    Scientific Reports, 7
  • [44] Phenylpropanoids from red kohlrabi sprouts inhibits nitric oxide production in RAW 264.7 macrophage cells
    Jae-Woong Lee
    Dae-Young Lee
    Dong-Ryeol Baek
    Rak-Hoon Jeong
    Dong-Sung Lee
    Youn-Chul Kim
    Geum-Soog Kim
    Nam-In Baek
    Youn-Hyung Lee
    Food Science and Biotechnology, 2014, 23 : 965 - 969
  • [45] Sesquiterpenes and lignans from the flower buds of Daphne genkwa and their nitric oxide inhibitory activities
    Zhang, Chun-Yang
    Luo, Lan
    Xia, Jing
    Song, Ya-Nan
    Zhang, Li-Jun
    Zhang, Miao
    Rahman, Khalid
    Ye, Yin
    Zhang, Hong
    Zhu, Jian-Yong
    NATURAL PRODUCT RESEARCH, 2018, 32 (24) : 2893 - 2899
  • [46] Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells
    Quang, DN
    Hashimoto, T
    Arakawa, Y
    Kohchi, C
    Nishizawa, T
    Soma, GI
    Asakawa, Y
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (01) : 164 - 168
  • [47] Yomogin inhibits the degranulation of mast cells and the production of the nitric oxide in activated RAW 264.7 cells
    Ryu, SY
    Oak, MH
    Kim, KM
    PLANTA MEDICA, 2000, 66 (02) : 171 - 173
  • [48] Phenylpropanoids from Red Kohlrabi Sprouts Inhibits Nitric Oxide Production in RAW 264.7 Macrophage Cells
    Lee, Jae-Woong
    Lee, Dae-Young
    Baek, Dong-Ryeol
    Jeong, Rak-Hoon
    Lee, Dong-Sung
    Kim, Youn-Chul
    Kim, Geum-Soog
    Baek, Nam-In
    Lee, Youn-Hyung
    FOOD SCIENCE AND BIOTECHNOLOGY, 2014, 23 (03) : 965 - 969
  • [49] Effect of Thalidomide on Nitric Oxide Production in Lipopolysaccharide-activated RAW 264.7 Cells
    Park, Eunkyue
    Levis, William K.
    Greig, Nigel
    Jung, Euisun
    Schuller-Levis, Georgia
    JOURNAL OF DRUGS IN DERMATOLOGY, 2010, 9 (04) : 330 - 333
  • [50] Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells
    Cho, KJ
    Han, SH
    Kim, BY
    Hwang, SG
    Park, KK
    Yang, KH
    Chung, AS
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2000, 166 (02) : 120 - 127
12345