Cadinane sesquiterpenes from Curcuma phaeocaulis with their inhibitory activities on nitric oxide production in RAW 264.7 cells

被引：19
|
作者：
Ma, Jianghao [1 ]
Wang, Ying [1 ]
Liu, Yue [1 ]
Gao, Suyu [1 ]
Ding, Liqin [2 ]
Zhao, Feng [3 ]
Chen, Lixia [1 ]
Qiu, Feng [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Dept Nat Prod Chem,Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
来源：
FITOTERAPIA | 2015年 / 103卷
基金：
中国国家自然科学基金;
关键词：
Curcuma phaeocaulis; Cadinane; Sesquiterpenes; Nitric oxide; Biogenetic pathway; GUAIANE-TYPE SESQUITERPENES; PARVIFLORENE-A; WENYUJIN; DIARYLHEPTANOIDS; KWANGSIENSIS; MACROPHAGES; EXTRACTS; RHIZOMES; LONGA;
D O I：
10.1016/j.fitote.2015.03.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new cadinane-type sesquiterpenes named phacadinanes A-D (1-4) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were elucidated by 1D and 2D NMR, as well as accurate mass measurements. Compound 4 was the first example of a rare 4,5-seco-cadinane sesquiterpene isolated from the Zingiberaceae family. Furthermore, inhibitory effects of the isolated compounds on nitric oxide production in LPS-activated macrophages were evaluated. Compounds 1 and 2 showed strong inhibitory activities on NO production with IC50 values of 3.88 +/- 058 and 225 +/- 0.71 mu M, respectively. A possible biogenetic pathway for 4,5-seco-cadinane sesquiterpene (4) was postulated. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：90 / 96
页数：7
相关论文
共 50 条
  • [21] Chemical constituents from Belamcanda chinensis and their inhibitory effects on nitric oxide production in RAW 264.7 macrophage cells
    Lee, Jin Woo
    Lee, Chul
    Jin, Qinghao
    Lee, Moon-Soon
    Kim, Youngsoo
    Hong, Jin Tae
    Lee, Mi Kyeong
    Hwang, Bang Yeon
    ARCHIVES OF PHARMACAL RESEARCH, 2015, 38 (06) : 991 - 997
  • [22] Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages
    Hwang, Ji Sang
    Lee, Seon A.
    Hong, Seong Su
    Han, Xiang Hua
    Lee, Chul
    Lee, Dongho
    Lee, Chong-Kil
    Hong, Jin Tae
    Kim, Youngsoo
    Lee, Mi Kyeong
    Hwang, Bang Yeon
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) : 706 - 708
  • [23] Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages
    Lee, Jin Woo
    Lee, Ji Hoon
    Lee, Chul
    Jin, Qinghao
    Lee, Dongho
    Kim, Youngsoo
    Hong, Jin Tae
    Lee, Mi Kyeong
    Hwang, Bang Yeon
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (04) : 960 - 962
  • [24] The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells
    Mu, MM
    Chakravortty, D
    Sugiyama, T
    Koide, N
    Takahashi, K
    Mori, I
    Yoshida, T
    Yokochi, T
    JOURNAL OF ENDOTOXIN RESEARCH, 2001, 7 (06): : 431 - 438
  • [25] Molecular mechanisms of inhibitory activities of tanshinones on Lipopolysaccharide-lnduced nitric oxide generation in RAW 264.7 cells
    Mong-Seok Choi
    Dong-lm Cho
    Hoo-Kyun Choi
    Suhn Yong Im
    Shi-Yong Ryu
    Kyeong-Man Kim
    Archives of Pharmacal Research, 2004, 27 : 1233 - 1237
  • [26] Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells
    Choi, HS
    Cho, DI
    Choi, HK
    Im, SY
    Ryu, SY
    Kim, KM
    ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (12) : 1233 - 1237
  • [27] Inhibition of nitric oxide production in RAW 264.7 cells by azaphilones from xylariaceous fungi
    Quang, DN
    Harinantenaina, L
    Nishizawa, T
    Hashimoto, T
    Kohchi, C
    Soma, GI
    Asakawa, Y
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (01) : 34 - 37
  • [28] Inhibitory action of eugenol compounds on the production of nitric oxide in RAW264.7 macrophages
    Li, Weihua
    Tsubouchi, Ryoko
    Qiao, Shanlou
    Haneda, Miyako
    Murakami, Keiko
    Yoshino, Masataka
    BIOMEDICAL RESEARCH-TOKYO, 2006, 27 (02): : 69 - 74
  • [29] Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages
    Lee, Chul
    Lee, Jin Woo
    Jin, Qinghao
    Jang, Dae Sik
    Lee, Sung-Joon
    Lee, Dongho
    Hong, Jin Tae
    Kim, Youngsoo
    Lee, Mi Kyeong
    Hwang, Bang Yeon
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (14) : 4263 - 4266
  • [30] Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells
    Jiang, Wen-Jun
    Daikonya, Akihiro
    Ohkawara, Mitsuyoshi
    Nemoto, Takashi
    Noritake, Ryusuke
    Takamiya, Tomoko
    Kitanaka, Susumu
    Iijima, Hiroshi
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (02) : 779 - 788
12345