Cadinane sesquiterpenes from Curcuma phaeocaulis with their inhibitory activities on nitric oxide production in RAW 264.7 cells

被引：19
|
作者：
Ma, Jianghao [1 ]
Wang, Ying [1 ]
Liu, Yue [1 ]
Gao, Suyu [1 ]
Ding, Liqin [2 ]
Zhao, Feng [3 ]
Chen, Lixia [1 ]
Qiu, Feng [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Dept Nat Prod Chem,Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
来源：
FITOTERAPIA | 2015年 / 103卷
基金：
中国国家自然科学基金;
关键词：
Curcuma phaeocaulis; Cadinane; Sesquiterpenes; Nitric oxide; Biogenetic pathway; GUAIANE-TYPE SESQUITERPENES; PARVIFLORENE-A; WENYUJIN; DIARYLHEPTANOIDS; KWANGSIENSIS; MACROPHAGES; EXTRACTS; RHIZOMES; LONGA;
D O I：
10.1016/j.fitote.2015.03.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new cadinane-type sesquiterpenes named phacadinanes A-D (1-4) were isolated from the rhizomes of Curcuma phaeocaulis. Their structures were elucidated by 1D and 2D NMR, as well as accurate mass measurements. Compound 4 was the first example of a rare 4,5-seco-cadinane sesquiterpene isolated from the Zingiberaceae family. Furthermore, inhibitory effects of the isolated compounds on nitric oxide production in LPS-activated macrophages were evaluated. Compounds 1 and 2 showed strong inhibitory activities on NO production with IC50 values of 3.88 +/- 058 and 225 +/- 0.71 mu M, respectively. A possible biogenetic pathway for 4,5-seco-cadinane sesquiterpene (4) was postulated. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：90 / 96
页数：7
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