β-Selective C-H Arylation of Electron-Deficient Thiophenes, Pyrroles, and Furans

被引：10

作者：

Liu, Luo-Yan ^{[1
]}

Qiao, Jennifer X. ^{[2
]}

Ewing, William R. ^{[2
]}

Yeung, Kap-Sun ^{[3
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst TSRI, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

[2] Bristol Myers Squibb, Discovery Chem, POB 4000, Princeton, NJ 08543 USA

[3] Bristol Myers Squibb Res & Dev, Discovery Chem, 100 Binney St, Cambridge, MA 02142 USA

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2020年 / 60卷 / 3-4期

关键词：

Thiophene; pyrrole; furan; palladium; arylation; ARYLBORONIC ACIDS; BOND ARYLATION; FUNCTIONALIZATION; ANILINES; CATALYST;

D O I：

10.1002/ijch.201900134

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general beta-C-H arylation of electron-deficient thiophenes, pyrroles, and furans has been developed using ligand-modulated palladium catalyst. The use of a modified norbornene is crucial for reversing the conventional alpha-selectivity of these substrates. This method features good yields, high beta-selectivity, and good tolerance of functional groups.

引用

页码：416 / 418

页数：3

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