GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy

被引：46

作者：

Labrada, Mayrel ^{[1
]}

Dorvignit, Denise ^{[1
]}

Hevia, Giselle ^{[1
]}

Rodriguez-Zhurbenko, Nely ^{[2
]}

Hernandez, Ana M. ^{[2
]}

Vazquez, Ana M. ^{[2
]}

Fernandez, Luis E. ^{[3
]}

机构：

[1] Ctr Mol Immunol CIM, Mol Immunol Inst, Immunobiol Div, Havana, Cuba

[2] CIM, Mol Immunol Inst, Tumor Biol Div, Havana, Cuba

[3] CIM, Mol Immunol Inst, Innovat Div, Havana, Cuba

来源：

SEMINARS IN ONCOLOGY | 2018年 / 45卷 / 1-2期

关键词：

GM3(Neu5Gc); immunotherapy; ganglioside; GlycoVaxGM3; Vaxira; 14F7hT; N-GLYCOLYLNEURAMINIC ACID; NONHUMAN SIALIC-ACID; CELL LUNG-CANCER; 1E10 ANTIIDIOTYPE VACCINE; ADVANCED BREAST-CANCER; MONOCLONAL-ANTIBODY; GM3; GANGLIOSIDE; NEUGCGM3; NGCGM3/VSSP VACCINE; XENO-AUTOANTIBODIES;

D O I：

10.1053/j.seminoncol.2018.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numerous molecules have been considered as targets for cancer immunotherapy because of their levels of expression on tumor cells, their putative importance for tumor biology, and relative immunogenicity. In this review we focus on the ganglioside GM3(Neu5Gc), a glycosphingolipid present on the outer side of the plasma membrane of vertebrate cells. The reasons for selecting GM3(Neu5Gc) as a tumor-specific antigen and its use as a target for cancer immunotherapy are discussed, together with the development of antitumor therapies focused on this target by the Center of Molecular Immunology (CIM, Cuba). (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：41 / 51

页数：11

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