GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy

被引：46
|
作者：
Labrada, Mayrel [1 ]
Dorvignit, Denise [1 ]
Hevia, Giselle [1 ]
Rodriguez-Zhurbenko, Nely [2 ]
Hernandez, Ana M. [2 ]
Vazquez, Ana M. [2 ]
Fernandez, Luis E. [3 ]
机构：
[1] Ctr Mol Immunol CIM, Mol Immunol Inst, Immunobiol Div, Havana, Cuba
[2] CIM, Mol Immunol Inst, Tumor Biol Div, Havana, Cuba
[3] CIM, Mol Immunol Inst, Innovat Div, Havana, Cuba
来源：
SEMINARS IN ONCOLOGY | 2018年 / 45卷 / 1-2期
关键词：
GM3(Neu5Gc); immunotherapy; ganglioside; GlycoVaxGM3; Vaxira; 14F7hT; N-GLYCOLYLNEURAMINIC ACID; NONHUMAN SIALIC-ACID; CELL LUNG-CANCER; 1E10 ANTIIDIOTYPE VACCINE; ADVANCED BREAST-CANCER; MONOCLONAL-ANTIBODY; GM3; GANGLIOSIDE; NEUGCGM3; NGCGM3/VSSP VACCINE; XENO-AUTOANTIBODIES;
D O I：
10.1053/j.seminoncol.2018.04.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Numerous molecules have been considered as targets for cancer immunotherapy because of their levels of expression on tumor cells, their putative importance for tumor biology, and relative immunogenicity. In this review we focus on the ganglioside GM3(Neu5Gc), a glycosphingolipid present on the outer side of the plasma membrane of vertebrate cells. The reasons for selecting GM3(Neu5Gc) as a tumor-specific antigen and its use as a target for cancer immunotherapy are discussed, together with the development of antitumor therapies focused on this target by the Center of Molecular Immunology (CIM, Cuba). (C) 2018 The Authors. Published by Elsevier Inc.
引用
收藏
页码：41 / 51
页数：11
相关论文
共 50 条
  • [21] Sialidases Neu1 and Neu3 on the surface of human monocyte-derived dendritic cells may influence cell activity by desialylating GM3 ganglioside
    Carubelli, Ivan
    Venerando, Bruno
    Stamatos, Nicholas M.
    GLYCOBIOLOGY, 2006, 16 (11) : 1159 - 1159
  • [22] Design, synthesis and biological evaluation of new ganglioside GM3 analogues as potential agents for cancer therapy
    Zheng, Changping
    Huang, Ruyi
    Bavaro, Teodora
    Terreni, Marco
    Sollogoub, Matthieu
    Xu, Jianhua
    Zhang, Yongmin
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 189
  • [23] LEVELS OF GANGLIOSIDE (GM3)-BOUND SIALIC-ACID ELEVATED IN SERA OF CANCER-PATIENTS
    MORRE, DJ
    MATYAS, G
    PIKAARD, D
    CHU, A
    PENNINGTON, K
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984, 25 (MAR): : 157 - 157
  • [24] Comparison of serum levels of Neu5Gc between normal and colorectal cancer patients with HPLC-MS/MS
    Ahn, S.
    Lee, H.
    Lim, H.
    Kim, Y.
    CLINICA CHIMICA ACTA, 2019, 493 : S70 - S70
  • [25] Structural analysis of trisialylated biantennary glycans isolated from mouse serum transferrin -: Characterization of the sequence Neu5Gc(α2-3)Gal(β1-3)[Neu5Gc(α2-6)]GlcNAc(β1-2)Man
    Coddeville, B
    Regoeczi, E
    Strecker, G
    Plancke, Y
    Spik, G
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2000, 1475 (03): : 321 - 328
  • [26] Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs
    Salama, A.
    Conchon, S.
    Perota, A.
    Martinet, B.
    Judor, J. -P.
    Evanno, G.
    Bernardet, S. Le-Bas
    Le Berre, L.
    Hervouet, J.
    Minault, D.
    Concordet, J. -P.
    Dugast, E.
    Vanhove, B.
    Abadie, J.
    Gaide, N.
    Lagutina, I.
    Duchi, R.
    Lazzari, G.
    Sachs, D.
    Gauthier, O.
    Brouard, S.
    Cozzi, E.
    Blancho, G.
    Perreault, H.
    Bach, J. -M.
    Galli, C.
    Soulillou, J. -P.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15
  • [27] One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics
    Wang, Juntao
    Lu, Dan
    Sun, Ran
    Lei, Shuwen
    Luo, Shuhua
    Dang, Xin
    Zhang, Yang
    Yuan, Chang
    Zhang, Yong
    Wu, Jinhong
    Yang, Guangyu
    Fu, Lei
    Jiang, Faqin
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (03) : 1883 - 1897
  • [28] Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc
    Springer, Stevan A.
    Diaz, Sandra L.
    Gagneux, Pascal
    IMMUNOGENETICS, 2014, 66 (11) : 671 - 674
  • [29] Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs
    Salama, Apolline
    Mosser, Mathilde
    Leveque, Xavier
    Perota, Andrea
    Judor, Jean-Paul
    Danna, Corentin
    Pogu, Sylvie
    Moure, Anne
    Jegou, Dominique
    Gaide, Nicolas
    Abadie, Jerome
    Gauthier, Olivier
    Concordet, Jean-Paul
    Le Bas-Bernardet, Stephanie
    Riochet, David
    Le Berre, Ludmilla
    Hervouet, Jeremy
    Minault, David
    Weiss, Pierre
    Guicheux, Jerome
    Brouard, Sophie
    Bosch, Steffi
    Lagutina, Irina
    Duchi, Roberto
    Lazzari, Giovanna
    Cozzi, Emanuele
    Blancho, Gilles
    Conchon, Sophie
    Galli, Cesare
    Soulillou, Jean-Paul
    Bach, Jean-Marie
    DIABETES, 2017, 66 (04) : 987 - 993
  • [30] Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc
    Stevan A. Springer
    Sandra L. Diaz
    Pascal Gagneux
    Immunogenetics, 2014, 66 : 671 - 674
12345