GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy

被引：46
|
作者：
Labrada, Mayrel [1 ]
Dorvignit, Denise [1 ]
Hevia, Giselle [1 ]
Rodriguez-Zhurbenko, Nely [2 ]
Hernandez, Ana M. [2 ]
Vazquez, Ana M. [2 ]
Fernandez, Luis E. [3 ]
机构：
[1] Ctr Mol Immunol CIM, Mol Immunol Inst, Immunobiol Div, Havana, Cuba
[2] CIM, Mol Immunol Inst, Tumor Biol Div, Havana, Cuba
[3] CIM, Mol Immunol Inst, Innovat Div, Havana, Cuba
来源：
SEMINARS IN ONCOLOGY | 2018年 / 45卷 / 1-2期
关键词：
GM3(Neu5Gc); immunotherapy; ganglioside; GlycoVaxGM3; Vaxira; 14F7hT; N-GLYCOLYLNEURAMINIC ACID; NONHUMAN SIALIC-ACID; CELL LUNG-CANCER; 1E10 ANTIIDIOTYPE VACCINE; ADVANCED BREAST-CANCER; MONOCLONAL-ANTIBODY; GM3; GANGLIOSIDE; NEUGCGM3; NGCGM3/VSSP VACCINE; XENO-AUTOANTIBODIES;
D O I：
10.1053/j.seminoncol.2018.04.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Numerous molecules have been considered as targets for cancer immunotherapy because of their levels of expression on tumor cells, their putative importance for tumor biology, and relative immunogenicity. In this review we focus on the ganglioside GM3(Neu5Gc), a glycosphingolipid present on the outer side of the plasma membrane of vertebrate cells. The reasons for selecting GM3(Neu5Gc) as a tumor-specific antigen and its use as a target for cancer immunotherapy are discussed, together with the development of antitumor therapies focused on this target by the Center of Molecular Immunology (CIM, Cuba). (C) 2018 The Authors. Published by Elsevier Inc.
引用
收藏
页码：41 / 51
页数：11
相关论文
共 50 条
  • [1] Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside
    Heinzelbecker, Julia
    Fauskanger, Marte
    Jonson, Ida
    Krengel, Ute
    Loset, Geir Age
    Munthe, Ludvig
    Tveita, Anders
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [2] Antitumor and cytotoxic properties of a humanized antibody specific for the GM3(Neu5Gc) ganglioside
    Dorvignit, Denise
    Garcia-Martinez, Liliana
    Rossin, Aurelie
    Sosa, Katya
    Viera, Justo
    Hernandez, Tays
    Mateo, Cristina
    Hueber, Anne-Odile
    Mesa, Circe
    Lopez-Requena, Alejandro
    IMMUNOBIOLOGY, 2015, 220 (12) : 1343 - 1350
  • [3] Large scale purification of gangliosides GM3(NeuSAc) and GM3(Neu5Gc) by trimethylaminoethyl-Fractogel high-performance liquid chromatography
    Heitmann, D
    Ziehr, H
    Muthing, J
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1998, 710 (1-2): : 1 - 8
  • [4] Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody
    G M Piperno
    A López-Requena
    A Predonzani
    D Dorvignit
    M Labrada
    L Zentilin
    O R Burrone
    M Cesco-Gaspere
    Gene Therapy, 2015, 22 : 960 - 967
  • [5] Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody
    Piperno, G. M.
    Lopez-Requena, A.
    Predonzani, A.
    Dorvignit, D.
    Labrada, M.
    Zentilin, L.
    Burrone, O. R.
    Cesco-Gaspere, M.
    GENE THERAPY, 2015, 22 (12) : 960 - 967
  • [6] Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells
    Denise Dorvignit
    Kayluz F. Boligan
    Ernesto Relova-Hernández
    Marilyn Clavell
    Armando López
    Mayrel Labrada
    Hans-Uwe Simon
    Alejandro López-Requena
    Circe Mesa
    Stephan von Gunten
    Scientific Reports, 9
  • [7] Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells
    Dorvignit, Denise
    Boligan, Kayluz F.
    Relova-Hernandez, Ernesto
    Clavell, Marilyn
    Lopez, Armando
    Labrada, Mayrel
    Simon, Hans-Uwe
    Lopez-Requena, Alejandro
    Mesa, Circe
    von Gunten, Stephan
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [8] Ganglioside GM3 and Its Role in Cancer
    Zheng, Changping
    Terreni, Marco
    Sollogoub, Matthieu
    Zhang, Yongmin
    CURRENT MEDICINAL CHEMISTRY, 2019, 26 (16) : 2933 - 2947
  • [9] AGGREGATION PROPERTIES OF GM3 GANGLIOSIDE (II3NEU5ACLACCER) IN AQUEOUS-SOLUTIONS
    SONNINO, S
    CANTU, L
    ACQUOTTI, D
    CORTI, M
    TETTAMANTI, G
    CHEMISTRY AND PHYSICS OF LIPIDS, 1990, 52 (3-4) : 231 - 241
  • [10] Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation
    Ghiroldi, Andrea
    Piccoli, Marco
    Creo, Pasquale
    Cirillo, Federica
    Rota, Paola
    D'Imperio, Sara
    Ciconte, Giuseppe
    Monasky, Michelle M.
    Micaglio, Emanuele
    Garatti, Andrea
    Aureli, Massimo
    Carsana, Emma Veronica
    Menicanti, Lorenzo
    Pappone, Carlo
    Anastasia, Luigi
    BIOCHEMICAL JOURNAL, 2020, 477 (17) : 3401 - 3415
12345