Pentacoordinated diorganotin(IV) complexes of Schiff base ligands: synthesis, characterization, antimicrobial and anticancer studies

In the present research work, a series of diorganotin(IV) complexes formulated as R2SnL1-5 (where R is butyl, methyl, phenyl and L1-5 are Schiff base ligands which were prepared by the reaction of 2-amino-6-bromo-4-chlorophenol with the salicylaldehyde derivatives) have been synthesized. The synthesized compounds have been characterized by elemental analysis and several instrumental techniques such as FTIR, NMR (H-1, C-13, and Sn-119), and mass spectrometry. The spectral results signified that the Schiff base ligands coordinated to tin atom in tridentate manner through ONO donor atoms. The Schiff base ligands and their corresponding complexes were biologically evaluated for antimicrobial efficacy against four bacterial strains and two fungal strains. The obtained results signified that phenyl substituted complexes had an edge over the butyl and methyl substituted complexes. Among all the synthesized compounds, complex 11 showed the best antimicrobial result against E. coli, P. aeruginosa and C. albicans. In addition, the anticancer activities of compounds 1-20 were evaluated against three cell lines. Complex 17 (IC50 value = 6.93 +/- 1.13 mu M) was found most active against the A549 cell line and showed comparable result with the standard drug paclitaxel (IC50 value= 2.98 +/- 1.04 mu M). [GRAPHICS] .